1184298-10-9

Basic information

• Product Name: 5-chloro-thiophene-2-carboxylic acid[(S)-2-[3-(5-chloro-1-methyl-2-oxo-1 ,2-dihydro-pyridin-3-yl)-2-ethyl-benzenesulfonylamino]-3-((S)-3-methyl-morpholin-4-yl)-3-oxo-propyl]-amide
• Synonyms: 5-chloro-thiophene-2-carboxylic acid[(S)-2-[3-(5-chloro-1-methyl-2-oxo-1 ,2-dihydro-pyridin-3-yl)-2-ethyl-benzenesulfonylamino]-3-((S)-3-methyl-morpholin-4-yl)-3-oxo-propyl]-amide
• CAS NO: 1184298-10-9
• Molecular Weight: 641.596
• Mol File: 1184298-10-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-chloro-thiophene-2-carboxylic acid[(S)-2-[3-(5-chloro-1-methyl-2-oxo-1 ,2-dihydro-pyridin-3-yl)-2-ethyl-benzenesulfonylamino]-3-((S)-3-methyl-morpholin-4-yl)-3-oxo-propyl]-amide(CAS DataBase Reference)
• NIST Chemistry Reference: 5-chloro-thiophene-2-carboxylic acid[(S)-2-[3-(5-chloro-1-methyl-2-oxo-1 ,2-dihydro-pyridin-3-yl)-2-ethyl-benzenesulfonylamino]-3-((S)-3-methyl-morpholin-4-yl)-3-oxo-propyl]-amide(1184298-10-9)
• EPA Substance Registry System: 5-chloro-thiophene-2-carboxylic acid[(S)-2-[3-(5-chloro-1-methyl-2-oxo-1 ,2-dihydro-pyridin-3-yl)-2-ethyl-benzenesulfonylamino]-3-((S)-3-methyl-morpholin-4-yl)-3-oxo-propyl]-amide(1184298-10-9)

Safety Data

• Hazardous Substances Data: 1184298-10-9(Hazardous Substances Data)

Upstream product

• 1184298-11-0 2-(3-benzylsulfanyl-2-ethyl-phenyl)-4,4,5,5-tetramethyl-[1 ,3,2]dioxaborolane 
• 1184297-41-3 (S)-2-(tert-butoxy)carbonylamino-3-[(5-chlorothiophene-2-carbonyl)amino]propionic acid methyl ester 
• 1184298-12-1 3-(3-benzylsulfanyl-2-ethyl-phenyl)-1-methyl-1H-pyridin-2-one 
• 1182728-08-0 1-benzylsulfanyl-3-bromo-2-ethylbenzene 
• 41053-30-9 1,3-dibromo-2-ethyl-benzene 
• 108-36-1 1,3-dibromobenzene 
• 42518-98-9 5-chlorothiophene-2-carbonyl chloride 
• 24065-33-6 5-Chlorothiophene-2-carboxylic acid 
• 81971-38-2 3-bromo-1-methyl-1H-pyridin-2-one 
• 13466-43-8 3-bromo-pyridin-2-ol 
• 1184298-13-2 3-(5-chloro-1-methyl-2-oxo-1 ,2-dihydro-pyridin-3-yl)-2-ethyl-benzenesulfonyl chloride 
• 1184297-38-8 5-chloro-thiophene-2-carboxylic acid [(S)-2-amino-3-((S)-3-methyl-morpholin-4-yl)-3-oxo-propyl]-amide 

Relevant articles and documents

CHLOROTHIOPHENE-AMIDES AS INHIBITORS OF COAGULATION FACTORS XA AND THROMBIN

The present invention relates to compounds of the formula I wherein R1; R2; R3; R4; R5, R13, R16, X and M have the meanings indicated in the claims. The compounds of formula I are valuable pharmacologically active compounds. They exhibit a strong anti-thrombotic effect and are suitable, for example, for the therapy and prophylaxis of cardio-vascular disorders like thromboembolic diseases or restenoses. They are reversible inhibitors of the blood clotting enzymes factor Xa (FXa) and thrombin and can in general be applied in conditions in which an undesired activity of factor Xa and/or thrombin are present or for the cure or prevention of which an inhibition of factor Xa and thrombin are intended. The invention furthermore relates to processes for the preparation of compounds of the formula I, their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical preparations comprising them.