118439-03-5

Basic information

• Product Name: diethyl (E)-1,1-difluoro-4-phenyl-3-butenephosphonate
• Synonyms: diethyl (E)-1,1-difluoro-4-phenyl-3-butenephosphonate
• CAS NO: 118439-03-5
• Molecular Weight: 304.274
• Mol File: 118439-03-5.mol

Chemical Properties

• CAS DataBase Reference: diethyl (E)-1,1-difluoro-4-phenyl-3-butenephosphonate(CAS DataBase Reference)
• NIST Chemistry Reference: diethyl (E)-1,1-difluoro-4-phenyl-3-butenephosphonate(118439-03-5)
• EPA Substance Registry System: diethyl (E)-1,1-difluoro-4-phenyl-3-butenephosphonate(118439-03-5)

Safety Data

• Hazardous Substances Data: 118439-03-5(Hazardous Substances Data)

Upstream product

• 4392-24-9 (Z)-cinnamyl bromide 
• 80077-72-1 diethyl difluoro(trimethylsilyl)methylphosphonate 
• 4392-24-9 Cinnamyl bromide 
• 1478-53-1 Diethyl difluoromethylphosphonate 
• 21087-29-6 trans-3-phenylprop-2-enyl chloride 
• 82845-20-3 [(diethoxyphosphoryl)difluoromethyl]zinc bromide 

Downstream Products

• 1300194-71-1 C₁₄H₁₈FO₃P 
• 1300194-64-2 C₁₄H₁₈FO₃P 

Relevant articles and documents

Allylations of zinc Bromide as a Convenient Route to 1,1-Difluoro-3-alkenephosphonates

The reaction of zinc bromide, (EtO)2P(O)CF2ZnBr, with allylic halides was found to be catalyzed by CuBr and represents a synthetically viable and convenient route to the title phosphonates.However, the reaction could no

Copper-Mediated Introduction of the CF2PO(OEt)2 Motif: Scope and Limitations

Herein, a general procedure to access CF2PO(OEt)2-containing molecules is reported. The reagent CuCF2PO(OEt)2 is accessible by a simple protocol and a broad range of substrates can be functionalised. The procedure allows the conversion of aryl diazonium salts, as well as aryl, heteroaryl, vinyl and alkynyl iodonium salts, into the corresponding fluorinated molecules at room temperature. Mechanistic studies were performed to gain a better understanding of the reaction pathway. Under similar conditions, vinyl and aryl iodides, allyl halides, and benzyl bromides were also functionalised, and the scope and limitations of the reaction were studied. Finally, the procedure was extended to disulfides to offer new access to SCF2PO(OEt)2-containing molecules.

Stereoselective synthesis of (E) α- Fluorovinylphosphonates from α,α-difluorophosphonates

α,α-Difluorophosphonates, which are readily available from alkyl halides and diethyl difluoromethylphosphonate, undergo elimination of hydrogen fluoride using alkali metal alkoxides to provide - fluorovinylphosphonates in high yields and E/Z selectivities. Georg Thieme Verlag Stuttgart New York.