118485-44-2

Usage

Uses

Used in Pharmaceutical Industry:
(E)-2-(4-methylbenzylidene)-3-phenyl-2,3-dihydro-1H-inden-1-one is used as a potential therapeutic agent for its antitumor properties. It has shown promise in preclinical studies and is considered a valuable target for further research and drug development in the fight against cancer.
Used in Antimalarial Applications:
In the field of infectious diseases, (E)-2-(4-methylbenzylidene)-3-phenyl-2,3-dihydro-1H-inden-1-one is used as a potential antimalarial agent. Its unique molecular structure and biological activities make it a promising candidate for the development of new treatments against malaria.

Upstream product

• 16618-72-7 3-phenyl-1-indanone 
• 104-87-0 4-methyl-benzaldehyde 
• 1666-17-7 benzaldehyde p-toluenesulfonylhydrazone 
• 1258504-66-3 C₁₆H₁₃IO 
• 551-93-9 2-aminoacetophenone 
• 2142-70-3 2-iodoacetophenone 
• 1576-35-8 toluene-4-sulfonic acid hydrazide 
• 1254271-38-9 (E)-1-(2-iodophenyl)-3-p-tolylprop-2-en-1-one 

Downstream Products

• 118485-30-6 C₃₇H₃₀N₂O₂ 
• 118485-29-3 C₃₇H₃₀N₂O 
• 118485-28-2 C₃₆H₂₈N₂O 

Relevant academic research and scientific papers

Phosphine-Free and Reusable Palladium Nanoparticles-Catalyzed Domino Strategy: Synthesis of Indanone Derivatives

The carbene migratory insertion involving a domino reaction by highly stable, reusable, and binaphthyl-stabilized Pd-nanoparticles (Pd-BNP) is disclosed. The reaction was catalyzed by 2 mol % of a heterogeneous Pd-BNP catalyst under external ligand-free c

Palladium-Catalyzed Intermolecular Carbene Insertion Prior to Intramolecular Heck Cyclization: Synthesis of 2-Arylidene-3-aryl-1-indanones

A domino process that converges the migratory insertion of carbene with a Heck reaction has been established as a versatile tool for the synthesis of 2-arylidene-3-aryl-1-indanones from very stable and easily accessible N-tosylhydrazones and 2′-iodochalco

Synthesis, characterization, biological evaluation and QSAR studies of 11-p-substituted phenyl-12-phenyl-11a,12-dihydro-11H-indeno[2,1-c][1,5] benzothiazepines as potential antimicrobial agents

A novel series of 11-p-substituted phenyl-12-phenyl-11a,12-dihydro-11H- indeno[2,1-c][1,5]benzothiazepines (3) has been synthesized and screened for their antimicrobial activity against Gram-positive (Bacillus subtilis and Staphylococcus aureus) and Gram-negative (Escherichia coli and Pseudomonas aeruginosa) bacteria and fungi (Aspergillus fumigates and Candida albicans). The antimicrobial evaluation data indicated that the compounds, 3d, 3g, 3h, 3k-3p exhibited very promising antibacterial activity and the derivatives 3k, 3l, 3o and 3p exhibited high antifungal activity. The QSAR studies carried out to find out the correlation between the antimicrobial activity and physicochemical properties of synthesized benzothiazepines (3) indicated the predominance of electronic parameters in describing their antimicrobial activity.