16618-72-7

Basic information

• Product Name: 3-PHENYL-1-INDANONE
• Synonyms: TIMTEC-BB SBB008151;3-PHENYLINDAN-1-ONE;3-PHENYL-1-INDANONE;AKOS BC-0964;1H-Inden-1-one, 2,3-dihydro-3-phenyl-;1H-Indene-1-one, 2,3-dihydro-3-phenyl-;1-Indanone, 3-phenyl-;2,3-dihydro-3-phenyl-1h-inden-1-on
• CAS NO: 16618-72-7
• Molecular Formula: C₁₅H₁₂O
• Molecular Weight: 208.26
• Product Categories: C15 to C38;Carbonyl Compounds;Ketones
• Mol File: 16618-72-7.mol
• Article Data: 61

Chemical Properties

• Melting Point: 75-78 °C(lit.)
• Boiling Point: 148 °C0.7 mm Hg(lit.)
• Flash Point: 142.3 °C
• Appearance: /
• Density: 1.162
• Vapor Pressure: 0.00016mmHg at 25°C
• Refractive Index: 1.5361 (estimate)
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 3-PHENYL-1-INDANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-PHENYL-1-INDANONE(16618-72-7)
• EPA Substance Registry System: 3-PHENYL-1-INDANONE(16618-72-7)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Safety Statements: 36
• WGK Germany: 3
• RTECS: NK7538200
• Hazardous Substances Data: 16618-72-7(Hazardous Substances Data)

Usage

General Description

3-Phenyl-1-indanone is a chemical compound with the molecular formula C15H12O. It is a white crystalline solid that is commonly used in the production of pharmaceuticals and as a fragrance additive in perfumes and cosmetics. 3-PHENYL-1-INDANONE is known for its aromatic and musky odor, and is often utilized in the creation of scents for personal care and household products. Additionally, 3-Phenyl-1-indanone has been studied for its potential medicinal properties, particularly in the treatment of neurodegenerative diseases and as an antimicrobial agent. Its unique molecular structure and versatile applications make it a valuable ingredient in a variety of industries.

InChI:InChI=1/C15H12O/c16-15-10-14(11-6-2-1-3-7-11)12-8-4-5-9-13(12)15/h1-9,14H,10H2/t14-/m0/s1

Upstream product

• 37089-77-3 3,3-diphenylpropanoyl chloride 
• 140-10-3 (E)-3-phenylacrylic acid 
• 71-43-2 benzene 
• 75-15-0 carbon disulfide 
• 7446-70-0 aluminium trichloride 
• 102-92-1 Cinnamoyl chloride 
• 621-82-9 Cinnamic acid 
• 102-92-1 cinnamoyl chloride 
• 300657-41-4 (E)-1-(2-bromophenyl)-3-phenylprop-2-en-1-one 
• 937792-81-9 ((2-benzylphenyl)ethynyl)trimethylsilane 
• 23450-18-2 2-benzyl-1-bromobenzene 
• 18982-54-2 o-bromobenzyl alcohol 
• 79137-23-8 1-(2-benzylphenyl)-2-diazoethanone 
• 107921-63-1 (E)-1-(2-iodophenyl)-3-phenylprop-2-en-1-one 

Downstream Products

• 337921-66-1 (+/-)-2-[(Ξ)-furfurylidene-3-phenyl-indan-1-one 
• 24387-73-3 1-Methyl-3-phenyl-indan-1-ol 
• 101729-18-4 2-dimethylaminomethyl-3-phenyl-indan-1-one 
• 102449-05-8 3-phenyl-2-piperidinomethyl-indan-1-one; hydrochloride 
• 5581-40-8 clothiapine 
• 860403-62-9 3-phenyl-2-(phenylamino)-1H-inden-1-one 
• 807263-03-2 methyl-(3-phenyl-indan-1-yl)-amine 
• 85803-90-3 endo-4-phenylbenzobicyclo<3.1.0>hex-2-ene 
• 26461-03-0 1-phenylindane 
• 84571-86-8 C₂₈H₂₃ClN₂ 
• 76773-33-6 1-Phenyl-2-deuterio-3-methylindene 
• 61198-52-5 3,4-dihydro-4-phenyl-2H-1-benzopyran-2-one 
• 24273-37-8 2-Hydroxyimino-3-phenyl-1-indanon 
• 77077-79-3 2-Hydroxy-4-phenylisocarbostyril 

Relevant articles and documents

First synthesis of 1-phenyl-3-pyrrol-1-ylindan-2-carboxylic acid, a new scaffold of potential non-peptide endothelin receptor antagonists

The first synthesis of trans, trans-1-phenyl-3-pyrrol-1-ylindan-2- carboxylic acid, a key-intermediate in the access to new potential non- peptide endothelin receptor antagonists, is reported.

Superacidic and HUSY-zeolite activation of 1,3-indandione: reactions with benzene and cyclohexane

1,3-Indandione (1) readily condenses with benzene and undergoes selective ionic hydrogenation with cyclohexane when activated by superacids, such as CF3SO3H, AlCl3 and AlBr3 to give 3,3-diphenyl-1-indanone (4) and 1-indanone (7), respectively. Combination of these reactions in 'one-pot' yields 3-phenyl-1-indanone (5). In addition, similar reactions have been carried out using the regenerable solid acid, HUSY-zeolite, providing an effective excess of acidic sites. The mechanism of these reactions, with potential involvement of superelectrophilic dicationic intermediates, is discussed.

Rh(I)-catalyzed intramolecular hydroacylation in ionic liquids

Rh(I)-catalyzed hydroacylation of 4-alkenal or 4,6-dienal using ionic liquids (ILs) as reaction media proceeded smoothly, giving cyclopentanone or cycloheptenone derivatives in good yields. It was found that the IL recovered after the reaction, which shou

Reactions of CF3-enones with arenes under superelectrophilic activation: A pathway to trans-1,3-diaryl-1-CF3-indanes, new cannabinoid receptor ligands

4-Aryl-1,1,1-trifluorobut-3-en-2-ones ArCHCHCOCF3 (CF3-enones) react with arenes in excess of Bronsted superacids (TfOH, FSO3H) to give, stereoselectively, trans-1,3-diaryl-1-trifluoromethyl indanes in 35-85% yields. The r

Versatile synthesis of 3-arylindan-1-ones by palladium-catalyzed intramolecular reductive cyclization of bromochalcones

We have developed a novel and versatile synthesis of racemic 3-arylindan-1-ones by palladium-catalyzed intramolecular reductive cyclization of bromochalcones. This method is especially attractive because it avoids strong acidic conditions and consequently a larger number of sensitive functional groups are accepted during synthesis compared with existing methods.

Construction of enantioenriched 9H-Fluorene frameworks via a cascade reaction involving remote vinylogous dynamic kinetic resolution

The benzylic C-H group of α,α-dicyanoolefins from 3-substituted 1-indanones could be significantly activated via transmission along the aromatic system, thus enabling dynamic kinetic resolution via a traditional reversible deprotonation- protonation process. Enantioenriched 9-substituted 9H-fluorene frameworks were finally constructed through an asymmetric vinylogous Michael addition to nitroolefins, followed by a cascade cyclization and oxidative aromatization process, under the catalysis of a chiral bifunctional thiourea-tertiary amine.

Iridium-Catalyzed Synthesis of Substituted Indanones from Aromatic Carboxylates and Unsaturated Ketones

A catalytic annulation is presented that provides straightforward, modular synthetic access to 3-substituted indanones from benzoic acids and α,β-unsaturated ketones. It is catalyzed by a bimetallic Ir/In system and proceeds via hydroarylation followed by