118493-33-7Relevant articles and documents
Application of Negishi cross-coupling to the synthesis of the cyclic tripeptides OF4949-III and K-13
Nolasco, Luca,Gonzalez, Manuel Perez,Caggiano, Lorenzo,Jackson, Richard F. W.
experimental part, p. 8280 - 8289 (2010/02/17)
(Chemical Equation Presented) Syntheses of the cyclic tripeptides OF4949-III 1 and K-13 2 are reported, in which the key steps are intermolecular and intramolecular Negishi cross-coupling reactions, respectively. In addition, the synthesis of a protected
Pd-catalysed C-C macrocyclisation of a simple tripeptide: Efficient total synthesis of K-13
Perez-Gonzalez,Jackson
, p. 2423 - 2424 (2007/10/03)
The cyclic tripeptide K-13 has been prepared in 11 steps from commercially available starting materials (11% overall yield); the key step is the Pd-catalysed macrocyclisation of the zinc reagent prepared by selective insertion of zinc into the aliphatic C
The total synthesis of the isodityrosine-derived cyclic tripeptides OF4949-III and K-13. Determination of the absolute configuration of K-13
Evans,Ellman
, p. 1063 - 1072 (2007/10/02)
The asymmetric syntheses of the two cyclic tripeptides OF4949-III and K-13 have been completed. The absolute stereochemical assignment of the former compound has been confirmed, while the absolute configuration of the latter has been established for the f