327621-04-5

Basic information

• Product Name: 2-(S)-[2-(S)-{2-(S)-tert-butoxycarbonylamino-3-[4-(5-iodo-2-methoxyphenoxy)phenyl]propionylamino}-3-(4-methoxyphenyl)-propionylamino]-3-hydroxypropionic acid methyl ester
• Synonyms: 2-(S)-[2-(S)-{2-(S)-tert-butoxycarbonylamino-3-[4-(5-iodo-2-methoxyphenoxy)phenyl]propionylamino}-3-(4-methoxyphenyl)-propionylamino]-3-hydroxypropionic acid methyl ester
• CAS NO: 327621-04-5
• Molecular Weight: 791.637
• Mol File: 327621-04-5.mol

Chemical Properties

• CAS DataBase Reference: 2-(S)-[2-(S)-{2-(S)-tert-butoxycarbonylamino-3-[4-(5-iodo-2-methoxyphenoxy)phenyl]propionylamino}-3-(4-methoxyphenyl)-propionylamino]-3-hydroxypropionic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(S)-[2-(S)-{2-(S)-tert-butoxycarbonylamino-3-[4-(5-iodo-2-methoxyphenoxy)phenyl]propionylamino}-3-(4-methoxyphenyl)-propionylamino]-3-hydroxypropionic acid methyl ester(327621-04-5)
• EPA Substance Registry System: 2-(S)-[2-(S)-{2-(S)-tert-butoxycarbonylamino-3-[4-(5-iodo-2-methoxyphenoxy)phenyl]propionylamino}-3-(4-methoxyphenyl)-propionylamino]-3-hydroxypropionic acid methyl ester(327621-04-5)

Safety Data

• Hazardous Substances Data: 327621-04-5(Hazardous Substances Data)

Upstream product

• 327621-03-4 2-(S)-tert-butoxycarbonylamino-3-[4-(5-iodo-2-methoxyphenoxy)phenyl]propionic acid methyl ester 
• 327621-01-2 2-(S)-tert-butoxycarbonylamino-3-[4-(2-formylphenoxy)phenyl]propionic acid 
• 327621-02-3 2-(S)-tert-butoxycarbonylamino-3-[4-(2-formylphenoxy)phenyl]propionic acid methyl ester 
• 193410-63-8 2-(S)-tert-butoxycarbonylamino-3-[4-(2-hydroxyphenoxy)phenyl]propionic acid methyl ester 
• 446-52-6 2-Fluorobenzaldehyde 
• 3978-80-1 Boc-Tyr-OH 
• 327621-00-1 2-(S)-tert-butoxycarbonylamino-3-[4-(5-iodo-2-methoxyphenoxy)phenyl]propionic acid 

Downstream Products

• 192315-55-2 15-(S)-tert-butoxycarbonylamino-4-methoxy-12-(S)-(4-methoxybenzyl)-11,14-dioxo-2-oxa-10,13-diazatricyclo[15.2.2.1(3,7)]-docosa-1-⁽²⁰⁾,3,5,7⁽²²⁾,17⁽²¹⁾,18-hexaene-9-(S)-carboxylic acid methyl ester 
• 118493-33-7 (9S,12S,15S)-15-Acetylamino-4-methoxy-12-(4-methoxy-benzyl)-11,14-dioxo-2-oxa-10,13-diaza-tricyclo[15.2.2.1^3,7]docosa-1⁽²⁰⁾,3,5,7⁽²²⁾,17⁽²¹⁾,18-hexaene-9-carboxylic acid methyl ester 
• 108890-90-0 K-13 
• 327620-98-4 2-(R)-[2-(S)-{2-(S)-tert-butoxycarbonylamino-3-[4-(5-iodo-2-methoxyphenoxy)phenyl]propionylamino}-3-(4-methoxyphenyl)-propionylamino]-3-iodopropionic acid methyl ester 

Relevant articles and documents

Application of Negishi cross-coupling to the synthesis of the cyclic tripeptides OF4949-III and K-13

(Chemical Equation Presented) Syntheses of the cyclic tripeptides OF4949-III 1 and K-13 2 are reported, in which the key steps are intermolecular and intramolecular Negishi cross-coupling reactions, respectively. In addition, the synthesis of a protected

Pd-catalysed C-C macrocyclisation of a simple tripeptide: Efficient total synthesis of K-13

The cyclic tripeptide K-13 has been prepared in 11 steps from commercially available starting materials (11% overall yield); the key step is the Pd-catalysed macrocyclisation of the zinc reagent prepared by selective insertion of zinc into the aliphatic C