1184949-91-4

Upstream product

• 1008518-26-0 5-(5-bromo-pyridin-2-ylmethoxy)-2-(tetrahydro-pyran-2-yl)-2H-pyridazin-3-one 
• 88139-91-7 (5-bromopyridin-2-yl)methanol 
• 75633-63-5 4-(hydroxymethyl)acetophenone 
• 1008517-95-0 2-bromo-1-[4-(hydroxymethyl)phenyl]ethanone 
• 1008518-25-9 5-(5-bromo-pyridin-2-ylmethoxy)-2H-pyridazin-3-one 

Downstream Products

• 1184946-70-0 5-(5-bromo-pyridin-2-ylmethoxy)-2-[2-(4-dimethylaminomethyl-phenyl)-2-oxo-ethyl]-2H-pyridazin-3-one 
• 1184949-89-0 2-[2-(4-bromomethyl-phenyl)-2-oxo-ethyl]-5-(5-bromo-pyridin-2-ylmethoxy)-2H-pyridazin-3-one 

Relevant academic research and scientific papers

Design, synthesis and evaluation of MCH receptor 1 antagonists - Part III: Discovery of pre-clinical development candidate BI 186908

Abstract Although overweight and obesity are highly prevalent conditions, options to treat them are still very limited. As part of our search for safe and effective MCH-R1 antagonists for the treatment of obesity, two series of pyridones and pyridazinones

PYRIDONE AND PYRIDAZINONE DERIVATIVES AS MCH ANTAGONISTS

The present invention relates to pyridone and pyridazinone derivatives as listed in claim 1 including their salts. Moreover the invention relates to pharmaceutical compositions containing at least one compound according to the invention. By virtue of thei