1184953-69-2Relevant academic research and scientific papers
One-pot Sonogashira coupling, hydroamination of alkyne and intramolecular C–H arylation reactions toward the synthesis of indole-fused benzosultams
Debnath, Sudarshan,Mondal, Shovan
supporting information, p. 2260 - 2263 (2018/05/23)
A one-pot Sonogashira coupling, hydroamination of alkyne and C–H arylation reactions for the synthesis of indole-fused benzosultams are described. This method allows access to a variety of indole-fused seven membered benzosultams in good to excellent yiel
Creation of molecular complexities via a new Cu-catalyzed cascade reaction: A direct access to novel 2,2′-spirobiindole derivatives
Prasad, Bagineni,Adepu, Raju,Sharma, Atul Kumar,Pal, Manojit
supporting information, p. 1259 - 1262 (2015/02/05)
A Cu-mediated unprecedented cascade reaction in the presence of air afforded a conceptually new synthesis of 2,2′-spirobiindole derivatives. This reaction proceeds via the rearrangement of several bonds in a cyclopenta[b]indole framework including a facial selective intramolecular ring closure. The potential of this method is highlighted in the straightforward and single step synthesis of a paullone like compound. This journal is
Spiro heterocycles as potential inhibitors of SIRT1: Pd/C-mediated synthesis of novel N-indolylmethyl spiroindoline-3,2′-quinazolines
Rambabu,Raja, Guttikonda,Yogi Sreenivas,Seerapu,Lalith Kumar,Deora, Girdhar Singh,Haldar, Devyani,Rao, M.V.Basaveswara,Pal, Manojit
supporting information, p. 1351 - 1357 (2013/03/14)
Novel N-indolylmethyl substituted spiroindoline-3,2′-quinazolines were designed as potential inhibitiors of SIRT1. These compounds were synthesized in good yields by using Pd/C-Cu mediated coupling-cyclization strategy as a key step involving the reaction of 1-(prop-2-ynyl)-1′H- spiro[indoline-3,2′-quinazoline]-2,4′(3′H)-dione with 2-iodoanilides. Some of the compounds synthesized have shown encouraging inhibition of Sir 2 protein (a yeast homologue of mammalian SIRT1) in vitro and three of them showed dose dependent inhibition of Sir 2. The docking results suggested that the benzene ring of 1,2,3,4-tetrahydroquinazolin ring system of these molecules occupied the deep hydrophobic pocket of the protein and one of the NH along with the sulfonyl group participated in strong H-bonding interaction with the amino acid residues.
Substituted 4-aminocyclohexane derivatives
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Page/Page column 20, (2009/09/07)
Substituted 4-aminocyclohexane derivatives having the formula I: [image] wherein R1-R4 are as described herein, methods for their preparation, medicinal products and pharmaceutical compositions containing these compounds and the use of substituted 4-amino
Pd/C-Mediated synthesis of indoles in water
Layek, Mohosin,Lakshmi, Udaya,Kalita, Dipak,Barange, Deepak K.,Islam, Aminul,Mukkanti, K.,Pal, Manojit
experimental part, (2010/04/22)
We describe the utility of a Pd/C-Cu mediated method in the synthesis of 2,s 5-disubstituted indoles in water via a coupling-cyclization strategy. Further application of this methodology has been demonstrated in the preparation of a target indole derivative via a 7-step process the key step being the Pd/C-mediated coupling reaction.
