118507-45-2

Upstream product

• 118507-44-1 t-butyl 4-fluoromethylbenzoate 
• 377732-82-6 4-(4-chlorobutyl)-5-ethyl-2-(p-tolyl)oxazole 
• 64299-49-6 4-(fluoromethyl)benzoic acid methyl ester 
• 6232-88-8 4-bromomethylbenzoic Acid 
• 115-11-7 isobutene 
• 6908-41-4 4-(methoxycarbonyl)benzyl alcohol 
• 1571-08-0 methyl 4-formylbenzoate 
• 99-94-5 p-Toluic acid 
• 108052-76-2 4-(bromomethyl)benzoic acid 1,1-dimethylethyl ester 
• 2417-72-3 Methyl 4-(bromomethyl)benzoate 

Downstream Products

• 223699-35-2 4-(fluoromethyl)benzoyl chloride 

Relevant academic research and scientific papers

Chemical tracer agent for fracturing as well as preparation method and application thereof

The invention relates to a chemical tracer for fracturing and a preparation method and application thereof. The chemical tracer agent is fluoromethyl benzoic acid. The preparation method of the chemical tracer takes p-chlorofluoromethyl benzene as an initial raw material, and comprises a preparation step of a fluoromethyl benzene Grignard reagent, a preparation step of fluoromethyl benzoate and a preparation step of fluoromethyl benzoic acid. The invention further provides application of p-fluoromethyl benzoic acid as a chemical tracer in oil exploitation, trace detection can be realized, and the detection precision is improved.

Transition-metal-free C-H oxidative activation: Persulfate-promoted selective benzylic mono- and difluorination

An operationally simple and selective method for the direct conversion of benzylic C-H to C-F to obtain mono- and difluoromethylated arenes using Selectfluor as a fluorine source is developed. Persulfate can be used to selectively activate benzylic hydrogen atoms toward C-F bond formation without the aid of transition metal catalysts.

LXR MODULATORS

The present invention provides compounds of Formula I: and pharmaceutically acceptable salts or solvates thereof, as modulators of liver X receptors (LXR), compositions comprising any of such novel compounds, methods of using these compounds or compositions as medicaments for prevention or treatment of diseases or disorders related to liver X receptor (LXR), as well as methods of preparing these LXR modulators and using them in the manufacture of medicaments.

Heterocyclic compounds

The present invention provides a preventive or therapeutic agent for hyperlipidemia, comprising as an active ingredient a heterocyclic compound of the formula [1], or a pharmaceutically acceptable salt thereof: R1-Het-D-E??[1] wherein: R1

No-carrier-added, 18F-labelling of a cholesterol derivative, used in detection of adrenal malignancies

[18F]Cholesteryl 4-(fluoromethyl)benzoate 6b was prepared from 3-cholesteryl [(4-nitrobenzenesulfonyl)oxymethyl]benzoate in one step using K+-Kryptofix 2.2.2, as counter ion and acetonitrile as the solvent at 40-60°C. The product was

Process for introducing fluorine into biologically active materials

Radioactive fluorine can be easily introduced into biologically active molecules containing amino groups. A p-bromomethyl benzoyl group is coupled to the amino group of the biologically active molecule, and bromine is displaced by fluorine. Alternatively,

A PROSTHETIC GROUP FOR THE RAPID INTRODUCTION OF FLUORINE INTO PEPTIDES AND FUNCTIONALIZED DRUGS

Fluoride ion as the tetrabutylammonium salt displaces bromide in para-substituted benzyl bromides in acetonitrile or dimethylformamide.The p-bromomethyl benzoyl (BMB) group has been coupled to amino groups, including peptide amino groups, via its N-hydrox