64299-49-6

Basic information

• Product Name: Benzoic acid, 4-(fluoromethyl)-, methyl ester
• Synonyms: 4-methylcarboxybenzyl fluoride;methyl 4-fluoromethylbenzoate;methyl 4-(fluoromethyl)benzoate;p-Fluormethylbenzoesaeuremethylester
• CAS NO: 64299-49-6
• Molecular Formula: C9H9FO2
• Molecular Weight: 168.168
• Mol File: 64299-49-6.mol
• Article Data: 18

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 4-(fluoromethyl)-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 4-(fluoromethyl)-, methyl ester(64299-49-6)
• EPA Substance Registry System: Benzoic acid, 4-(fluoromethyl)-, methyl ester(64299-49-6)

Safety Data

• Hazardous Substances Data: 64299-49-6(Hazardous Substances Data)

Upstream product

• 1415115-07-9 C₁₄H₁₂FNO₄S 
• 619-44-3 methyl 4-iodobenzoate 
• 74105-54-7 methyl 4-(hydrazineylidenemethyl)benzoate 
• 2967-66-0 methyl 4-(trifluoromethyl)benzoate 
• 2417-72-3 Methyl 4-(bromomethyl)benzoate 
• 99768-12-4 4-methoxycarbonylphenylboronic acid 
• 373-53-5 fluoroiodomethane 
• 171364-80-0 methyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate 
• 1571-08-0 methyl 4-formylbenzoate 
• 6908-41-4 4-(methoxycarbonyl)benzyl alcohol 
• 99-75-2 4-methyl-benzoic acid methyl ester 

Downstream Products

• 223699-35-2 4-(fluoromethyl)benzoyl chloride 
• 22744-12-3 [4-(methoxycarbonyl)phenyl]acetic acid 
• 444915-76-8 methyl 4-(difluoromethyl)benzoate 
• 118507-45-2 4-monofluoromethylbenzoic acid 

Relevant articles and documents

Visible-light photoredox-catalyzed selective carboxylation of C(sp3)?F bonds with CO2

It is highly attractive and challenging to utilize carbon dioxide (CO2), because of its inertness, as a nontoxic and sustainable C1 source in the synthesis of valuable compounds. Here, we report a novel selective carboxylation of C(sp3)?F bonds with CO2 via visible-light photoredox catalysis. A variety of mono-, di-, and trifluoroalkylarenes as well as α,α-difluorocarboxylic esters and amides undergo such reactions to give important aryl acetic acids and α-fluorocarboxylic acids, including several drugs and analogs, under mild conditions. Notably, mechanistic studies and DFT calculations demonstrate the dual role of CO2 as an electron carrier and electrophile during this transformation. The fluorinated substrates would undergo single-electron reduction by electron-rich CO2 radical anions, which are generated in situ from CO2 via sequential hydride-transfer reduction and hydrogen-atom-transfer processes. We anticipate our finding to be a starting point for more challenging CO2 utilization with inert substrates, including lignin and other biomass.

METHOD AND REAGENT FOR DEOXYFLUORINATION

A safe, simple, and selective method and reagent for deoxyfluorination is disclosed. With the method and reagent disclosed herein, organic compounds such as carboxylic acids, carboxylates, carboxylic acid anhydrides, aldehydes, and alcohols can be fluorinated by using the most common nucleophilic fluorinating reagents and electron deficient fluoroarenes as mediators under mild conditions, giving corresponding fluoroorganic compounds in excellent yield with a wide range of functional group compatibility and easy product purification. For example, directly utilizing KF for deoxyfluorination of carboxylic acids provides the most economical and the safest pathway to access acyl fluorides, key intermediates for syntheses of peptide, amide, ester, and dry fluoride salts.

Quaternary Ammonium Trifluoromethoxide Salts as Stable Sources of Nucleophilic OCF3

The reaction of nucleophilic tertiary amines with trifluoromethyl and pentafluoroethyl methyl ethers provides quaternary ammonium trifluoromethoxide (NR4OCF3) and pentafluoroethoxide (NR4OCF2CF3) salts, respectively, in good yields. The new trifluoromethoxide salts disclosed herein are uniquely stable for extended periods of time in both the solid state and in solution, which complements contemporary reagents. Here we describe the preparation of a range of NR4OCF3 salts, their long-term stability, and utility in substitution reactions.