118535-63-0

Basic information

• Product Name: (S)-(-)-1-amino-2-(1'-methoxy-1',1'-diphenylmethyl)pyrrolidine
• Synonyms: (S)-(-)-1-amino-2-(1'-methoxy-1',1'-diphenylmethyl)pyrrolidine
• CAS NO: 118535-63-0
• Molecular Weight: 282.385
• Mol File: 118535-63-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-(-)-1-amino-2-(1'-methoxy-1',1'-diphenylmethyl)pyrrolidine(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-(-)-1-amino-2-(1'-methoxy-1',1'-diphenylmethyl)pyrrolidine(118535-63-0)
• EPA Substance Registry System: (S)-(-)-1-amino-2-(1'-methoxy-1',1'-diphenylmethyl)pyrrolidine(118535-63-0)

Safety Data

• Hazardous Substances Data: 118535-63-0(Hazardous Substances Data)

Upstream product

• 5817-26-5 ethyl (2S)-pyrrolidine-2-carboxylate 
• 147-85-3 L-proline 
• 118970-99-3 (S)-(-)-1-benzyl-2-(1-methoxy-1,1-diphenylmethyl)-pyrrolidine 
• 118970-95-9 (S)-1-benzyl-2-(hydroxydiphenylmethyl)pyrrolidine 
• 118971-03-2 (S)-(-)-2-(1-methoxy-1,1-diphenylmethyl)-pyrrolidine 
• 955-40-8 N-benzyl-L-proline ethyl ester 
• 118535-72-1 1-nitroso-2-(1'-methoxy-1',1'-diphenyl)pyrrolidine 

Downstream Products

• 118535-65-2 (1-Benzyl-2-phenyl-ethylidene)-[(S)-2-(methoxy-diphenyl-methyl)-pyrrolidin-1-yl]-amine 
• 1422543-80-3 C₄₃H₅₀N₄O₂ 
• 220956-09-2 [(S)-2-Benzyloxy-2-trifluoromethyl-non-(E)-ylidene]-[(S)-2-(methoxy-diphenyl-methyl)-pyrrolidin-1-yl]-amine 
• 220956-07-0 [(S)-2-Benzyl-2-benzyloxy-3,3,3-trifluoro-prop-(E)-ylidene]-[(S)-2-(methoxy-diphenyl-methyl)-pyrrolidin-1-yl]-amine 
• 220956-08-1 (2S,2'S)-1-[2'-benzyloxy-2'-phenyl-3',3',3'-(trifluoro)propyleneamino]-2-(1''-methoxy-1'',1''-diphenyl)pyrrolidine 
• 220956-02-5 (S)-1,1,1-Trifluoro-2-{[(E)-(S)-2-(methoxy-diphenyl-methyl)-pyrrolidin-1-ylimino]-methyl}-nonan-2-ol 
• 220956-17-2 (2S,2'S)-1-[2'-methoxy-2'-(trifluoromethyl)nonyleneamino]-2-(1''-methoxy-1'',1''-diphenyl)pyrrolidine 
• 220955-98-6 (S)-2-Benzyl-1,1,1-trifluoro-3-[(E)-(S)-2-(methoxy-diphenyl-methyl)-pyrrolidin-1-ylimino]-propan-2-ol 
• 220956-15-0 [(S)-2-Benzyl-3,3,3-trifluoro-2-methoxy-prop-(E)-ylidene]-[(S)-2-(methoxy-diphenyl-methyl)-pyrrolidin-1-yl]-amine 
• 220956-06-9 [(S)-2-Benzyloxy-3,3,3-trifluoro-2-methyl-prop-(E)-ylidene]-[(S)-2-(methoxy-diphenyl-methyl)-pyrrolidin-1-yl]-amine 
• 220956-16-1 [(S)-2-(Methoxy-diphenyl-methyl)-pyrrolidin-1-yl]-[(S)-3,3,3-trifluoro-2-methoxy-2-phenyl-prop-(E)-ylidene]-amine 

Relevant articles and documents

LARGE SCALE PREPARATION OF VERSATILE CHIRAL AUXILIARIES DERIVED FROM (S)-PROLINE

The synthesis of a variety of enantiomerically pure chiral auxiliaries based on (S)-proline and bearing sterically demanding side chains at the pyrrolidine moiety, such as the secondary amines (S)-3,5 and 7 and the hydrazines (S)-6, is described on a molar scale.As key step, the Grignard or RLi addition to the N-benzylated proline ester (S)-1 is used.