118535-75-4

Upstream product

• 118535-88-9 [(S)-2-Benzyloxy-3-phenyl-prop-(Z)-ylidene]-[(S)-2-(1-ethyl-1-methoxy-propyl)-pyrrolidin-1-yl]-amine 
• 123394-79-6 (S)-2-(benzyloxy)-1-hydroxy-3-phenylpropane 
• 81927-55-1 O-benzyl 2,2,2-trichloroacetimidate 
• 110351-28-5 (S)-2-(benzyloxy)-3-phenylpropanoic acid methyl ester 
• 118535-68-5 [(S)-2-(1-Ethyl-1-methoxy-propyl)-pyrrolidin-1-yl]-[3-phenyl-prop-(Z)-ylidene]-amine 
• 104-53-0 3-phenyl-propionaldehyde 
• 20312-36-1 L-3-phenyllactic acid 
• 188295-04-7 (2S)-2-hydroxy-N-methoxy-N-methyl-3-phenylpropanamide 
• 13673-95-5 (S)-methyl 2-hydroxy-3-phenylpropanoate 
• 100-39-0 benzyl bromide 

Downstream Products

• 160423-10-9 ((1S,2S)-2-Benzyloxy-1-hydroxy-3-phenyl-propyl)-phosphonic acid dimethyl ester 
• 125225-52-7 (5S,1'S)-5-(1'-hydroxy-2'-phenylethyl)dihydrofuran-2(3H)-one 
• 155295-58-2 5(S)-[1(S)-benzyloxy-2-phenylethyl]dihydrofuran-2(3H)-one 
• 220588-83-0 5(S)-[1(S)-[(tert-butyldimethylsilyl)oxy]-2-phenylethyl]dihydrofuran-2(3H)-one 
• 155295-59-3 5(S)-[1(S)-benzyloxy-2-phenylethyl]-3(R)-(2-propenyl)dihydrofuran-2(3H)-one 
• 155295-60-6 5(S)-[1(S)-benzyloxy-2-phenylethyl]-3(R)-(cyclopropylmethyl)dihydrofuran-2(3H)-one 
• 220588-84-1 5(S)-[2-phenyl-1(S)-[(tert-butyldimethylsilyl)oxy]ethyl]-3(S)-(2-thienylmethyl)dihydrofuran-2(3H)-one 
• 220589-05-9 (2S,4S,5S)-4,5-Bis-(tert-butyl-dimethyl-silanyloxy)-6-phenyl-2-thiophen-2-ylmethyl-hexanoic acid 
• 155295-62-8 N-[1(S)-(cyclohexylmethyl)-2(R),3(S)-dihydroxy-5-methylhexyl]-2(R)-(cyclopropylmethyl)-5(S)-benzyloxy-4(S)-hydroxy-6-phenylhexanamide 

Relevant academic research and scientific papers

A Br?nsted Acid Catalyzed Cascade Reaction for the Conversion of Indoles to α-(3-Indolyl) Ketones by Using 2-Benzyloxy Aldehydes

A Br?nsted acid catalyzed, operationally simple, scalable route to several functionalized α-(3-indolyl) ketones has been developed and the long-standing regioisomeric issue has been eliminated by choosing appropriate carbonyls. A readily available and cheap bottle reagent was used as the catalyst. This protocol was also applicable to the synthesis of densely functionalized α-(3-pyrrolyl) ketones. A detailed mechanistic study confirmed the involvement of enolether as a reaction intermediate. Several postsynthetic modifications along with easy access to β-carboline, tryptamines, tryptophols, and spiro-indolenine proclaim the synthetic utility of this powerful building block. On the basis of this concept, functionalized carbazoles were constructed by a cascade annulation strategy.

Asymmetric induction in methyl ketone aldol additions to α-alkoxy and α,β-bisalkoxy aldehydes: A model for acyclic stereocontrol

A systematic study of methyl ketone aldol additions under nonchelating conditions with α-alkoxy and α,β-bisalkoxy aldehydes is described. Additions to aldehydes containing a single α-alkoxy stereocenter generally provide the product diastereomers in accor

Novel small renin inhibitors containing 4,5- or 3,5-Dihydroxy-2-substituted-6-phenylhexanamide replacements at the P2-P3 sites

Renin inhibitors containing a 4,5- or a 3,5-dihydroxy-2-substituted-6-phenylhexanamide fragment at the P2-P3 sites have been prepared and evaluated. The four possible diastereomeric diols of the two series of inhibitors were synthesi

RENIN INHIBITING POLYHYDROXY-MONOAMIDES

Disclosed herein are compounds of the formula:R 1 CH 2 CH(X)CH(Y)CH(Z)CHR 2 C(O)NHCHR 3 CH(OH) CH(OH)R 4wherein R 1 is a terminal unit, for example lower cycloalkyl or phenyl; R 2 is, for example, an optionally substituted alkyl, cycloalkylme

ENANTIOSELECTIVE SYNTHESIS OF PROTECTED α-HYDROXY ALDEHYDES AND KETONES VIA HYDROXYLATION OF METALATED CHIRAL HYDRAZONES

α-Benzyloxy aldehydes and α-acetoxy ketones 4 of high enantiomeric purity are prepared in good overall yields via oxaziridine mediated hydroxylation of chiral hydrazone azaenolates.As auxiliaries novel proline derived hydrazine reagents 5 are used.