123394-79-6

Basic information

• Product Name: (S)-2-(benzyloxy)-1-hydroxy-3-phenylpropane
• Synonyms: (S)-2-(benzyloxy)-1-hydroxy-3-phenylpropane
• CAS NO: 123394-79-6
• Molecular Weight: 242.318
• Mol File: 123394-79-6.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: (S)-2-(benzyloxy)-1-hydroxy-3-phenylpropane(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-(benzyloxy)-1-hydroxy-3-phenylpropane(123394-79-6)
• EPA Substance Registry System: (S)-2-(benzyloxy)-1-hydroxy-3-phenylpropane(123394-79-6)

Safety Data

• Hazardous Substances Data: 123394-79-6(Hazardous Substances Data)

Upstream product

• 81927-55-1 O-benzyl 2,2,2-trichloroacetimidate 
• 13673-95-5 (S)-methyl 2-hydroxy-3-phenylpropanoate 
• 110351-28-5 (S)-2-(benzyloxy)-3-phenylpropanoic acid methyl ester 
• 100-58-3 phenylmagnesium bromide 
• 108-86-1 bromobenzene 
• 123483-75-0 (4S,5R)-1-benzyloxyacetyl-3,4-dimethyl-5-phenyl-imidazolidin-2-one 
• 19810-31-2 Benzyloxyacetyl chloride 
• 173180-05-7 (S)-1-(tert-Butyl-diphenyl-silanyloxy)-3-phenyl-propan-2-ol 
• 98819-68-2 3-phenyl-(2R,3R)-oxiran-2-ylmethanol 
• 17131-14-5 (S)-(-)-3-phenyl-1,2-propanediol 
• 100-39-0 benzyl bromide 
• 20312-36-1 L-3-phenyllactic acid 
• 173180-07-9 ((S)-2-Benzyloxy-3-phenyl-propoxy)-tert-butyl-diphenyl-silane 
• 123483-76-1 (4R,5S,2'S)-1,5-dimethyl-4-phenyl-3-(2'-benzyloxy-3'-phenylpropanoyl)imidazoldin-2-one 

Downstream Products

• 220588-85-2 4(S),5(S)-bis[(tert-butyldimethylsilyl)oxy]-N-[1(S)-(cyclohexylmethyl)-2(R),3(S)-dihydroxy-5-methylhexyl]-6-phenyl-2(S)-(2-thienylmethyl)hexanamide 
• 155295-61-7 N-[1(S)-(cyclohexylmethyl)-2(R),3(S)-dihydroxy-5-methylhexyl]-5(S)-benzyloxy-4(S)-[(tert-butyldimethylsilyl)oxy]-2(R)-(cyclopropylmethyl)-6-phenylhexanamide 
• 155295-62-8 N-[1(S)-(cyclohexylmethyl)-2(R),3(S)-dihydroxy-5-methylhexyl]-2(R)-(cyclopropylmethyl)-5(S)-benzyloxy-4(S)-hydroxy-6-phenylhexanamide 
• 220589-05-9 (2S,4S,5S)-4,5-Bis-(tert-butyl-dimethyl-silanyloxy)-6-phenyl-2-thiophen-2-ylmethyl-hexanoic acid 
• 220588-84-1 5(S)-[2-phenyl-1(S)-[(tert-butyldimethylsilyl)oxy]ethyl]-3(S)-(2-thienylmethyl)dihydrofuran-2(3H)-one 
• 155295-60-6 5(S)-[1(S)-benzyloxy-2-phenylethyl]-3(R)-(cyclopropylmethyl)dihydrofuran-2(3H)-one 
• 155295-59-3 5(S)-[1(S)-benzyloxy-2-phenylethyl]-3(R)-(2-propenyl)dihydrofuran-2(3H)-one 
• 220588-83-0 5(S)-[1(S)-[(tert-butyldimethylsilyl)oxy]-2-phenylethyl]dihydrofuran-2(3H)-one 
• 155295-58-2 5(S)-[1(S)-benzyloxy-2-phenylethyl]dihydrofuran-2(3H)-one 

Relevant articles and documents

A Br?nsted Acid Catalyzed Cascade Reaction for the Conversion of Indoles to α-(3-Indolyl) Ketones by Using 2-Benzyloxy Aldehydes

A Br?nsted acid catalyzed, operationally simple, scalable route to several functionalized α-(3-indolyl) ketones has been developed and the long-standing regioisomeric issue has been eliminated by choosing appropriate carbonyls. A readily available and cheap bottle reagent was used as the catalyst. This protocol was also applicable to the synthesis of densely functionalized α-(3-pyrrolyl) ketones. A detailed mechanistic study confirmed the involvement of enolether as a reaction intermediate. Several postsynthetic modifications along with easy access to β-carboline, tryptamines, tryptophols, and spiro-indolenine proclaim the synthetic utility of this powerful building block. On the basis of this concept, functionalized carbazoles were constructed by a cascade annulation strategy.

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Renin inhibitors containing a 4,5- or a 3,5-dihydroxy-2-substituted-6-phenylhexanamide fragment at the P2-P3 sites have been prepared and evaluated. The four possible diastereomeric diols of the two series of inhibitors were synthesi

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