118552-55-9 Usage
Uses
Used in Pharmaceutical Synthesis:
N-BOC-DL-PIPECOLINIC ACID is used as a building block for the preparation of various pharmaceutical agents and bioactive compounds. Its BOC protecting group allows for controlled reactions, facilitating the synthesis of complex molecules with specific therapeutic properties.
Used in Peptide Synthesis:
In the field of peptide synthesis, N-BOC-DL-PIPECOLINIC ACID is utilized as a key component. The BOC group protects the amine functionality, enabling the stepwise assembly of peptide chains with precise control over the reaction conditions. This results in the production of peptides with desired sequences and biological activities.
Used in Organic Chemistry:
N-BOC-DL-PIPECOLINIC ACID is also employed in organic chemistry for the synthesis of various organic compounds. The BOC protecting group allows for selective reactions, enabling the formation of specific products with high yields and purity.
Check Digit Verification of cas no
The CAS Registry Mumber 118552-55-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,8,5,5 and 2 respectively; the second part has 2 digits, 5 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 118552-55:
(8*1)+(7*1)+(6*8)+(5*5)+(4*5)+(3*2)+(2*5)+(1*5)=129
129 % 10 = 9
So 118552-55-9 is a valid CAS Registry Number.
InChI:InChI=1/C11H19NO4/c1-11(2,3)16-10(15)12-7-5-4-6-8(12)9(13)14/h8H,4-7H2,1-3H3,(H,13,14)/p-1/t8-/m0/s1
118552-55-9Relevant academic research and scientific papers
Discovery of 23 Natural Tubulysins from Angiococcus disciformis An d48 and Cystobacter SBCb004
Chai, Yi,Pistorius, Dominik,Ullrich, Angelika,Weissman, Kira J.,Kazmaier, Uli,Mueller, Rolf
experimental part, p. 296 - 309 (2010/06/19)
The tubulysins are a family of complex peptides with promising cytotoxic activity against multi-drug-resistant tumors. To date, ten tubulysins have been described from the myxobacterial strains Angiococcus disciformis An d48 and Archangium gephyra Ar 315. We report here a third producing strain, Cystobacter sp. SBCb004. Comparison of the tubulysin biosynthetic gene clusters in SBCb004 and An d48 reveals a conserved architecture, allowing the assignment of cluster boundaries. A SBCb004 strain containing a mutant in the putative cyclodeaminase gene tubZ accumulates pretubulysin A, the proposed first enzyme-free intermediate in the pathway, whose structure we confirm by NMR. We further show, using a combination of feeding studies and structure elucidation by NMR and high-resolution tandem mass spectrometry, that SBCb004 and An d48 together biosynthesize 22 additional tubulysin derivatives. These data reveal the inherently diversity-oriented nature of the tubulysin biosynthetic pathway.
