118574-86-0Relevant academic research and scientific papers
Preparation of Chiral Lactones from L-Lactic Acid via (S)-γ-Methyltetronic Acid
Brandaege, Svante,Jansbo, Kerstin,Minassie, Teclay
, p. 736 - 739 (2007/10/02)
(S)-γ-Methyltetronic acid (1), prepared in two high-yield steps from ethyl L-lactate, has been reduced to chiral building blocks.Reduction with ammonia-borane gave mainly the trans-alcohol 2t.A new route to butenolide 3 led to a higher optical properties of 3 was attained by five previous routes.An efficient procedure provided the saturated lactone 5 in two steps from 1.
