1185742-22-6

Basic information

• Product Name: 3(5)-(4-Fluorophenyl)-1H-pyrazole
• Synonyms: 3(5)-(4-Fluorophenyl)-1H-pyrazole
• CAS NO: 1185742-22-6
• Molecular Formula: C₉H₇FN₂
• Molecular Weight: 162.1636832
• Mol File: 1185742-22-6.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3(5)-(4-Fluorophenyl)-1H-pyrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 3(5)-(4-Fluorophenyl)-1H-pyrazole(1185742-22-6)
• EPA Substance Registry System: 3(5)-(4-Fluorophenyl)-1H-pyrazole(1185742-22-6)

Safety Data

• Hazardous Substances Data: 1185742-22-6(Hazardous Substances Data)

Upstream product

• 766-98-3 1-ethynyl-4-fluorobenzene 
• 73789-56-7 N-isocyaniminotriphenylphosphorane 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 1028092-46-7 5-(4-fluorophenyl)-1-(tetrahydropyran-2-yl)-1H-pyrazole 
• 75175-77-8 3-(dimethylamino)-1-(4-fluorophenyl)prop-2-en-1-one 

Downstream Products

• 1335210-57-5 C₂₃H₁₅FN₂ 

Relevant articles and documents

Molybdenum-silver co-catalyzed cycloaddition of alkynes with: N -isocyanoiminotriphenylphosphorane (NIITP): An efficient strategy for the synthesis of monosubstituted pyrazoles

A new molybdenum-silver co-catalyzed [3+2] cycloaddition of alkynes with N-isocyanoiminotriphenylphosphorane (NIITP) has been described. The NIITP serves as a non-toxic, facile "CNN" source. Over 30 substrates were successfully converted to the desired compounds in good to excellent yields.

Discovery and in vitro and in vivo profiles of N-ethyl-N-[2-[3-(5-fluoro-2-pyridinyl)-1H-pyrazol-1-yl]ethyl]-2-(2H-1,2,3-triazol-2-yl)-benzamide as a novel class of dual orexin receptor antagonist

Orexins play an important role in sleep/wake regulation, and orexin receptor antagonists are a focus of novel therapy for the treatment of insomnia. We identified 27e (TASP0428980) as a potent dual orexin receptor antagonist through the systematic modification of our original designed lead A. We demonstrated the potent sleep-promoting effects of 27e at ip dose of 3 mg/kg in a rat polysomnogram study. 27e exhibited relatively short half-life profiles in rats and dogs. Furthermore, accumulating evidence regarding ADME profiles indicates that the predicted human half-life of 27e should be 1.2-1.4 h. These data indicated that 27e has a short-acting hypnotic property, suggesting that 27e might be useful for treating primary insomnia while exhibiting a low risk of next-day residual somnolence. Thus, 27e and its related compounds should be further evaluated to enable advancement to clinical trials.

An efficient solvent-free synthesis of NH-pyrazoles from β-dimethylaminovinylketones and hydrazine on grinding

A series of NH-pyrazoles was efficiently synthesized from the reaction of β-dimethylaminovinylketones ([R1C(O)C(R2){double bond, long}CHN(Me2)], where R1 = Me, Ph, 3-MeO-Ph, 4-Me-Ph, 4-MeO-Ph, 4-F-Ph, 4-Cl-Ph, 4