118604-70-9Relevant academic research and scientific papers
Chiral ferrocene-imidazole diphosphine ligand as well as synthesis method and application thereof
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Paragraph 0047-0051; 0064-0067, (2021/05/22)
The invention relates to a chiral ferrocene-imidazole diphosphine ligand as well as a preparation method and application thereof. The synthesis method comprises the following steps: dissolving ferrocenyl chiral alcohol and N, N '-carbonyldiimidazole, whic
Method for preparing chiral amine compound through asymmetric hydrogenation of imine under catalysis of palladium
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Paragraph 0056; 0057; 0090-0093, (2021/05/22)
The invention discloses a method for preparing a chiral amine compound through asymmetric hydrogenation of imine under the catalysis of palladium. The chiral palladium catalyst adopted by the method is generated in situ from a metal palladium precursor and a chiral ferrocene-imidazole diphosphine ligand in various solvents. The method has the advantages of cheap catalyst, simple ligand preparation, mild reaction conditions, simple operation, high yield and enantioselectivity, reaction under normal pressure and hydrogen pressure, realization of continuous operation, and suitableness for large-scale preparation of chiral amine compounds. The method is also suitable for synthesis of the key intermediate of the herbicide (S)-metolachlor, the yield can reach 95%, the enantioselectivity can reach 90%, and the method has good industrial application prospects.
Method for preparing chiral amine compound through nickel-catalyzed imine asymmetric hydrogenation
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Paragraph 0055-0058; 0087-0090, (2021/05/22)
The invention discloses a method for preparing a chiral amine compound through nickel-catalyzed imine asymmetric hydrogenation. The nickel catalyst adopted by the method is generated in situ from a metal nickel precursor and a chiral ferrocene-imidazole d
Method for preparing chiral amine through iridium catalyzed imine asymmetric hydrogenation
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Paragraph 0049; 0076-0079, (2021/05/22)
The invention discloses a method for preparing chiral amine through iridium catalyzed imine asymmetric hydrogenation. The iridium catalyst adopted by the method is generated in situ from a metal iridium precursor and a chiral diphosphine ligand in various polar and non-polar solvents, and the dosage (by mole) of the catalyst is as follows: raw material imine/catalyst (S/C) is equal to 300,000-1000,000. The method is simple in ligand preparation, low in catalyst dosage, simple and convenient to operate, capable of achieving continuous operation and suitable for large-scale preparation of chiral amine, and the enantiomeric excess value (ee value) of the product reaches 80% or above. According to the present invention, the S-metolachlor key intermediate synthesis catalyst consumption is low, the 2-ethyl-6-methylaniline/catalyst (S/C) is 500000, the yield can achieve 95%, the enantioselectivity can achieve 91%, and the good industrial application range is provided.
Compound herbicide based on dichloro quinolinic acid
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Paragraph 0021; 0031; 0039; 0041; 0049; 0051; 0059, (2021/11/21)
The invention discloses a compound herbicide based on quinclorac, which comprises 20 - 30 parts of quinclorac. Dichloromethane 3-8 parts, synergist 10 - 20 parts, wetting agent 1.5 - 4.5 parts, dispersing agent 1-3 parts, defoaming agent 0.5 - 2.5 parts and water 50 - 70 parts. The synergist inhibits the growth of cells by hindering the synthesis of the protein, and the sprouts of monocotyledonous plants are obtained through young buds of plants. The lower endoderm of the dicotyledonous plant is absorbed and conducted upwards, the seeds and roots absorb conduction, the absorption amount is low, the conduction speed is slow, the growth of young buds and roots is inhibited.
Chiral mono-dentate phosphine ligand asymmetric hydrogenation imine method based on D - mannitol (by machine translation)
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Paragraph 0079-0083, (2020/07/06)
The chiral mono-dentate phosphine ligand derived based on D - mannide is prepared by reacting D - mannitol-derived chiral mono-dentate phosphine ligand and a metal iridium precursor in situ to prepare the complex as a catalyst, and imine asymmetric hydrogenation to prepare chiral amine. Suitable catalyst amounts (in terms of mol) are: The raw material imine/catalyst (S/C) is equal 100 - 10000. The ligand is simple to prepare, low in catalyst consumption and simple and convenient to operate, can realize continuous operation, is suitable for large-scale preparation of chiral amine, ee value of the product reaches 75percent or more, and can meet the requirement of a pesticide intermediate. The method has good results for the synthesis of the metolachlor intermediate, and has good industrial applicability. (by machine translation)
Method for asymmetric reductive amination of ketone based on fructose-derived pyridinol chiral ligand
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Paragraph 0087-0091, (2020/07/06)
The invention discloses a method for asymmetric reductive amination of ketone based on a fructose-derived pyridinol chiral ligand, which comprises the following steps: reacting a fructose-derived pyridinol chiral ligand with a metal iridium precursor to prepare a complex in situ as a catalyst, and carrying out direct asymmetric reductive amination on ketone and amine to prepare chiral amine. The ligand disclosed by the invention is simple to prepare, the catalyst dosage is low, the operation is simple and convenient, continuous operation can be realized, the method is suitable for large-scalepreparation of chiral amine, the enantiomeric excess value of the product reaches 70% or above, and the requirement of serving as a pesticide intermediate can be met. The method has a good result whenthe 2-ethyl-6-methylaniline/catalyst (S/C) is 10000 during synthesis of an s-metolachlor intermediate, the yield is 95%, the enantioselectivity is 75%, and the method has good industrial practicability.
Method for asymmetric reductive amination based on fructose-derived chiral monodentate phosphite ligand ketone
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Paragraph 0085-0089, (2020/07/06)
The invention discloses a method for preparing chiral amine based on asymmetric reductive amination of fructose-derived chiral monodentate phosphite ligand ketone, which comprises the following steps:reacting fructose-derived chiral monodentate phosphite ligand with a metal iridium precursor to prepare a complex in situ as a catalyst, and carrying out direct asymmetric reductive amination on ketone and amine to prepare chiral amine. The ligand disclosed by the invention is simple to prepare, the catalyst dosage is low, the operation is simple and convenient, continuous operation can be realized, the method is suitable for large-scale preparation of chiral amine, the enantiomeric excess value of the product reaches 80% or above, and the requirement of serving as a pesticide intermediate can be met. The method disclosed by the invention has a relatively good result when 2-ethyl-6-methylaniline/catalyst (S/C) is 10000 during synthesis of an s-metolachlor intermediate, the yield is 95%, the enantioselectivity is 85%, and the method has very good industrial practicability.
Method for preparing chiral amine through asymmetric hydrogenation based on glucose-derived monodentate phosphite ligand
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Paragraph 0080-0084, (2020/07/06)
The invention discloses a method for preparing chiral amine through asymmetric hydrogenation based on a glucose-derived monodentate phosphite ligand. The method comprises the following steps: reactinga chiral glucose-derived monodentate phosphite ligand with a metal iridium precursor to prepare a complex in situ as a catalyst, and carrying out asymmetric hydrogenation on imine to prepare chiral amine. The proper catalyst dosage (by mole) is as follows: the raw material imine/catalyst (S/C) is equal to 100-500,000. The ligand disclosed by the invention is simple to prepare, the catalyst dosageis low, the operation is simple and convenient, continuous operation can be realized, the method is suitable for large-scale preparation of chiral amine, the enantiomeric excess (ee value) of the product reaches 70% or above, and the requirement of serving as a pesticide intermediate can be met. According to the method, a good result is obtained for synthesis of an s-metolachlor intermediate, andthe method has good industrial practicability.
Iridium/chiral phosphite ester-pyridine catalyzed imine asymmetric hydrogenation method
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Paragraph 0061-0066; 0071-0074; 0081-0082, (2019/12/25)
The invention discloses a method for catalyzing asymmetric hydrogenation of imines with iridium/chiral phosphite ester-pyridine, which comprises the following steps: reacting a chiral phosphite ester-pyridine (P, N) ligand with a metal iridium precursor to prepare a complex in situ as a catalyst, and carrying out asymmetric hydrogenation on an imine to prepare a chiral amine. The ligand is simpleto prepare; catalyst dosage is low, operation is simple, continuous operation can be realized, the preparation method is simple in process and suitable for large-scale preparation of chiral amines, the enantiomeric excess value of the product reaches 85% or above, the preparation method is excellent in effect in result when the S/C (2-ethyl-6-methylaniline/catalyst) rate is 500,000 during synthesis of the s-metolachlor intermediate, the yield is 95%, the enantioselectivity is 91%, and good industrial practicability is achieved.
