23652-67-7Relevant articles and documents
Chiral diphosphine ligand rhodium complex containing tetra (3, 5-bis (trifluoromethylphenyl) boron anions and preparation method and application thereof
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Paragraph 0056-0065, (2021/10/27)
The invention relates to a chiral diphosphine ligand rhodium complex containing tetra (3, 5-bis (trifluoromethylphenyl) boron anions and a preparation method and application thereof. Specifically, the high-stability chiral diphosphine ligand rhodium complex containing BArF anions can be obtained by complexing a chiral diphosphine ligand with a rhodium salt and then carrying out anion exchange with NaBArF. The complex can efficiently catalyze an asymmetric catalytic hydrogenation reaction of beta-dehydroamino acid ester to prepare a beta-amino acid ester derivative with high optical purity, so that a synthetic method suitable for industrialization is provided for optically pure beta-amino acid and beta-amino alcohol, and the complex has a good application prospect.
Hypervalent iodane mediated reactions of: N -acetyl enamines for the synthesis of oxazoles and imidazoles
Xu, Kang,Yang, Ruiqi,Yang, Shuang,Jiang, Cheng,Ding, Zhenhua
supporting information, p. 8977 - 8981 (2019/10/28)
A hypervalent iodane reagent used for the intramolecular cyclization of N-acetyl enamines and intermolecular cyclocondensation of enamines and nitriles was investigated. The reaction was performed under mild conditions and gave oxazoles and imidazoles, respectively, in moderate to excellent yields. This transformation exhibits good reactivity, selectivity and functional group tolerance. The selectivity of the intra- or intermolecular reaction is dependent on the structure of N-acetyl enamines.
Nickel-catalyzed enantioselective hydrogenation of β-(acylamino)acrylates: Synthesis of chiral β-amino acid derivatives
Li, Xiuxiu,You, Cai,Li, Shuailong,Lv, Hui,Zhang, Xumu
supporting information, p. 5130 - 5133 (2017/11/06)
The nickel-catalyzed asymmetric hydrogenation of β-(acylamino)acrylates has been developed, affording chiral β-amino acid derivatives with excellent yields (95-99% yield) and enantioselectivities (97-99% ee). With the Ni-Binapine system, high enantioselectivities (98-99% ee) have also been obtained in the hydrogenation of Z/E isomeric mixtures of β-alkyl and β-aryl β-(acylamino)acrylates. The synthesis of chiral β-amino acid derivatives on a gram scale has also been achieved with 0.2 mol % catalyst loading.