1186304-20-0Relevant articles and documents
Dicardinin S derivative as well as preparation method and application thereof
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, (2021/10/27)
The invention provides a dibenzylidine S derivative and a preparation method and application thereof, and the derivative has the structure shown I. R1 . R2 Each is independently selected from hydrogen, methyl, (CH). 2 )n R9 , (R C9 . R3 Is H or - (CH)2 )n R9 . R5 . R6 , R7 , R8 Each is independently selected from hydrogen, hydroxy, methyl, halogen, nitro and amino. R9 An amino group and 5-6 元 nitrogen-containing ring. The 5-6 元 nitrogen-containing ring may optionally contain, or not contain, another hetero atom oxygen atom. The amino group and 5-6 元 nitrogen-containing ring may be unsubstituted or selected from C. 1 -5 Alkyl. C1 -5 Haloalkyl, hydroxy, phenyl and substituted C1 -5 Alkoxy or halogen substituted phenyl, R10 S (＝ O)2 At least one substituent in - is substituted. R10 Be selected from C1 -5 Alkyl, 5 - RMB 6 nitrogen-containing rings, n Is 1 or 2. In-flight R1 , R2 Not at the same time methyl.
Synthesis of macrocyclic bisbibenzyl derivatives and their anticancer effects as anti-tubulin agents
Jiang, Juan,Sun, Bin,Wang, Yan-Yan,Cui, Min,Zhang, Li,Cui, Chang-Zhi,Wang, Yan-Feng,Liu, Xi-Gong,Lou, Hong-Xiang
scheme or table, p. 2382 - 2391 (2012/05/05)
Based on the core skeleton of the total synthesized bisbibenzyl marchantin C, riccardin D and plagiochin E, a series of brominated and aminomethylated derivatives of above three bisbibenzyls have been synthesized and their cytotoxic activity against KB, M
