1186485-58-4

Upstream product

• 126629-81-0 methyl 3-(4-bromophenyl)-3-oxopropanoate 
• 99-90-1 para-bromoacetophenone 
• 103-83-3 N,N'-dimethylbenzylamine 
• 127-19-5 N,N-dimethyl acetamide 

Relevant academic research and scientific papers

Diamine-mediated degradative dimerisation of Morita-Baylis-Hillman ketones

A degradative dimerisation of Morita-Baylis-Hillman ketones was observed in the presence of a primary diamine. The reaction proceeded swiftly to produce methylene-bridged 1,3-dicarbonyl compounds. A brief mechanistic investigation alluded to a retro-Mannich reaction as the key step of the transformation.

Metal-free Csp3-N bond cleavage of amides using tert-butyl hydroperoxide as oxidant

A mild and efficient protocol for the metal-free C-N bond-cleavage of amides has been developed. The methodology employs iodine as a catalyst to cleave the C(Me)-N bond of dimethylformamide or dimethylacetamide, providing novel access to methylene-bridged bis-1,3-dicarbonyl compounds instead of enol carbamates in the presence of tert-butyl hydroperoxide.

Aerobic oxidation of a tertiary aliphatic amine under visible-light photocatalysis: Facile synthesis of methylene-bridged bis-1,3-dicarbonyl compounds

Lights, camera, action! An efficient protocol for the formation of methylene-bridged bis-1,3-dicarbonyl compounds has been developed through an aerobic photocatalytic oxidative coupling reaction between 1,3-dicarbonyl compounds and a tertiary aliphatic amine. Copyright

Gold/copper-catalyzed activation of the aci-form of nitromethane in the synthesis of methylene-bridged bis-1,3-dicarbonyl compounds

Activation of the aci-form of nitromethane using Lewis acids for the attack of carbon nucleophiles was studied. 1,3-Dicarbonyl compounds in the presence of catalytic amounts of AuCl3 or Cu(OTf)2 in nitromethane solvent could be converted into methylene-bridged bis-1,3-dicarbonyl compounds.