118653-08-0

Upstream product

• 67-56-1 methanol 
• 36650-51-8 (2E)-3-(4-methoxyphenyl)acrylamide 
• 83421-79-8 p-methoxycinnamoyl azide 

Downstream Products

• 18797-94-9 N-[(1E)-2-(4-methoxyphenyl)ethenyl]acetamide 
• 118653-19-3 Acetyl-[(E)-2-(4-methoxy-phenyl)-vinyl]-carbamic acid methyl ester 
• 118653-30-8 (2-Bromo-propionyl)-[(E)-2-(4-methoxy-phenyl)-vinyl]-carbamic acid methyl ester 

Relevant academic research and scientific papers

A facile approach to arylacetaldehydes via polymeric palladium catalyst

Several arylacetaldehydes 5 were synthesized in moderate yields via Heck reaction of acrylamide (1) with substituted iodobenzenes 2 in the presence of the polymeric catalyst (P)-phenyl-(1,10-phenanthroline)-palladium(0) [(P)-ph-phen·Pd(0)] followed by Hofmann reaction and subsequent hydrolysis.

Synthesis of Enamides

(Z)-3-Arylprop-2-enoic acids can be converted by the Curtius procedure, through the acyl azides, into (Z)-2-arylethenyl isocyanates, which with methanol give methyl (Z)-N-(2-arylethenyl)carbamates.Acylation of the (Z)-enecarbamates, through their anions, leads to methyl (Z)-N-acyl-N-(2-arylethenyl)carbamates, which on treatment with lithium iodide in boiling N,N-dimethylformamide or acetonitrile undergo demethoxycarbonylation to give (Z)-enamides.The stereospecific route to enamides can also be used in the E-series.Treatment of (Z)- or (E)-2-arylethenyl isocyanates with trifluoroacetic acid gives (E)-N-(2-arylethenyl)trifluoroacetamides,the anions of which, with acylating agents, give (E)-enamides directly.