118671-39-9

Upstream product

• 118693-23-5 N-(2-Benzenesulfonylmethyl-4-chloro-phenyl)-N-benzyl-2-chloro-acetamide 
• 1810-67-9 6-chloroquinolin-2(1H)-oney 
• 100-39-0 benzyl bromide 
• 118671-06-0 4-chloro-N-(phenylmethyl)-2-(phenylsulfonylmethyl)benzenamine 
• 100-52-7 benzaldehyde 
• 118671-02-6 2-Benzenesulfonylmethyl-4-chloro-phenylamine 

Relevant academic research and scientific papers

Visible light-induced one-pot synthesis of CF3/CF2-substituted cyclobutene derivatives

An efficient one-pot approach for the controllable synthesis of trifluoromethyl/gem-difluoromethylene substituted cyclobutene derivatives has been developed. The mechanism may involve visible light-induced [2+2]-cycloaddition of quinolinones with 1-bromo-1-trifluoromethylethene, followed by base-promoted dehydrobromination, [1,3]-H shift and further dehydrofluorination. A variety of CF3/CF2-substituted cyclobutenes that are currently difficult to obtain are afforded in good yields in this protocol, which may find its way into future fluorinated cyclobutene preparation.

Synihesis of 3-substituied indoles via a modified madeling reaction

Anilides 4a-c,e-k, lla-d in which the amide function is benzylated, or silylated and having different electron-withdrawing groups (EWG) at the methyl methyl in the ortho position of the amide function, cyclize under the influence of potassium tert-butoxide to the corresponding indole derivatives 5a-c,e-k and 9a-d, respectively, under these conditions the chloroacetamides 4d,n and 11e are converted into the tetrahydroquinolines 6a,b and 12, respectively. Treatment of chloroacetamide 4m with KOt-Bu gave, in addition to starting material, indole 5m, tetrahydroquinoline 6c and 2(1H)-quinolinone 7. When 3-indolecarbonitrile 5a is treated with sodium in liquid amnonia debenzylation takes place, while after catalytic hydrogenation with 5% Pd/C the corresponding 2,3-dirnethylindole 8 is formed.