1187056-38-7

Basic information

• Product Name: ethyl 2-(2,6-difluorophenyl)thiazole-4-carboxylate
• Synonyms: ethyl 2-(2,6-difluorophenyl)thiazole-4-carboxylate
• CAS NO: 1187056-38-7
• Molecular Formula: C₁₂H₉F₂NO₂S
• Molecular Weight: 269.2671664
• Mol File: 1187056-38-7.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: ethyl 2-(2,6-difluorophenyl)thiazole-4-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-(2,6-difluorophenyl)thiazole-4-carboxylate(1187056-38-7)
• EPA Substance Registry System: ethyl 2-(2,6-difluorophenyl)thiazole-4-carboxylate(1187056-38-7)

Safety Data

• Hazardous Substances Data: 1187056-38-7(Hazardous Substances Data)

Usage

General Description

Ethyl 2-(2,6-difluorophenyl)thiazole-4-carboxylate is a chemical compound with the molecular formula C13H9F2NO2S. It is a thiazole derivative with a carboxylate functional group. Ethyl 2-(2,6-difluorophenyl)thiazole-4-carboxylate is commonly used in the pharmaceutical industry as a building block for the synthesis of various heterocyclic compounds with potential biological activity. Its unique structure and properties make it an important intermediate in the development of new drugs and agrochemicals. Additionally, it has potential applications in the field of materials science and organic synthesis. Due to its role in drug development, it is important for researchers and chemists to have access to high-quality and pure samples of Ethyl 2-(2,6-difluorophenyl)thiazole-4-carboxylate for their studies and experiments.

Upstream product

• 60230-33-3 2,6-difluorobenzothioamide 
• 70-23-5 ethyl Bromopyruvate 
• 1378830-51-3 ethyl bromo-pyruvic acid 
• 18063-03-1 2,6-difluorobenzamide 
• 1187056-41-2 ethyl 5-amino-2-(2,6-difluorophenyl)thiazole-4-carboxylate 
• 863868-37-5 2-(2,6-difluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 100367-77-9 ethyl 2-bromothiazole-4-carboxylate 

Downstream Products

• 1017452-64-0 2-(2,6-difluorophenyl)-1,3-thiazole-4-carboxylic acid 
• 1620011-23-5 tert-butyl {(3S)-1-[5-({[2-(2,6-difluorophenyl)-1,3-thiazol-4-yl]carbonyl}amino)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]piperidin-3-yl}carbamate 
• 1620011-22-4 N-{4-[(3S)-3-aminopiperidin-1-yl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-2-(2,6-difluorophenyl)-1,3-thiazole-4-carboxamide 
• 1620011-65-5 C₂₈H₃₁F₂N₅O₄S 
• 1620011-31-5 N-{4-[(3S)-3-aminopiperidin-1-yl]-2,3-dihydrofuro[2,3-b]pyridin-5-yl}-2-(2,6-difluorophenyl)-1,3-thiazole-4-carboxamide 
• 1620011-41-7 tert-butyl {(3S)-1-[3-({[2-(2,6-difluorophenyl)-1,3-thiazol-4-yl]carbonyl}amino)-6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl]piperidin-3-yl}carbamate 
• 1620011-35-9 N-{4-[(3S)-3-aminopiperidin-1-yl]-6,7-dihydro-5H-cyclopenta[b]pyridin-3-yl}-2-(2,6-difluorophenyl)-1,3-thiazole-4-carboxamide 
• 1620011-52-0 4-{(3S)-3-[(tert-butoxycarbonyl)amino]piperidin-1-yl}-3-({[2-(2,6-difluorophenyl)-1,3-thiazol-4-yl]carbonyl}amino)-6,7-dihydro-5H-cyclopenta[b]pyridin-7-yl acetate 
• 1620011-51-9 N-{4-[(3S)-3-aminopiperidin-1-yl]-7-hydroxy-6,7-dihydro-5H-cyclopenta[b]pyridin-3-yl}-2-(2,6-difluorophenyl)-1,3-thiazole-4-carboxamide 
• 1620012-27-2 N-{4-[(3S)-3-aminopiperidin-1-yl]-1H-pyrazolo[3,4-b]pyridin-5-yl}-2-(2,6-difluorophenyl)-1,3-thiazole-4-carboxamide 
• 1620011-04-2 tert-butyl {(3S)-1-[3-({[2-(2,6-difluorophenyl)-1,3-thiazol-4-yl]carbonyl}amino)quinolin-4-yl]piperidin-3-yl}carbamate 
• 1620011-03-1 N-{4-[(3S)-3-aminopiperidin-1-yl]quinolin-3-yl}-2-(2,6-difluorophenyl)-1,3-thiazole-4-carboxamide 
• 1620011-11-1 tert-butyl {(3S)-1-[5-({[2-(2,6-difluorophenyl)-1,3-thiazol-4-yl]carbonyl}amino)thieno[2,3-b]pyridin-4-yl]piperidin-3-yl}carbamate 
• 1620011-10-0 N-{4-[(3S)-3-aminopiperidin-1-yl]thieno[2,3-b]pyridin-5-yl}-2-(2,6-difluorophenyl)-1,3-thiazole-4-carboxamide 

Relevant articles and documents

A Strecker approach to 2-substituted ethyl 5-aminothiazole-4-carboxylates

A general approach to 2-substituted ethyl 5-aminothiazole-4-carboxylates is reported herein. Both aliphatic and aromatic thioamides undergo 1,2-addition to ethyl glyoxylate to give hemiaminals which, when treated with acetyl chloride, undergo elimination

Identification of N-(4-((1R,3S,5S)-3-amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide (PIM447), a potent and selective proviral insertion site of Moloney murine leukemia (PIM) 1, 2, and 3 kinase inhibitor in clinical trials for hematological malignancies

Pan proviral insertion site of Moloney murine leukemia (PIM) 1, 2, and 3 kinase inhibitors have recently begun to be tested in humans to assess whether pan PIM kinase inhibition may provide benefit to cancer patients. Herein, the synthesis, in vitro activity, in vivo activity in an acute myeloid leukemia xenograft model, and preclinical profile of the potent and selective pan PIM kinase inhibitor compound 8 (PIM447) are described. Starting from the reported aminopiperidyl pan PIM kinase inhibitor compound 3, a strategy to improve the microsomal stability was pursued resulting in the identification of potent aminocyclohexyl pan PIM inhibitors with high metabolic stability. From this aminocyclohexyl series, compound 8 entered the clinic in 2012 in multiple myeloma patients and is currently in several phase 1 trials of cancer patients with hematological malignancies.

THIAZOLECARBOXAMIDES AND PYRIDINECARBOXAMIDE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS

The present disclosure describes thiazole and pyridine carboxamide derivatives, their compositions and methods of use. The compounds inhibit the activity of the Pim kinases and are useful in the treatment of diseases related to the activity of Pim kinases including, e.g., cancer and other diseases.