60230-33-3

Usage

Uses

Used in Pharmaceutical Industry:
2,6-difluorobenzene-1-carbothioamide serves as a crucial intermediate in the synthesis of various pharmaceuticals. Its unique structure and reactivity contribute to the development of new drugs with improved therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical sector, 2,6-difluorobenzene-1-carbothioamide is utilized in the production of pesticides and other agrochemicals. Its incorporation enhances the effectiveness of these products, promoting more efficient pest control and crop protection.
Used in Dye and Pigment Manufacturing:
2,6-difluorobenzene-1-carbothioamide is employed in the manufacturing of dyes and pigments due to its ability to impart color and stability to these products. Its use results in dyes and pigments with enhanced performance characteristics.
Used in Polymer Production:
2,6-difluorobenzene-1-carbothioamide also finds application in the production of polymers, where it contributes to the development of polymers with specific properties. Its incorporation can lead to polymers with improved strength, durability, or other desirable attributes.
Used in Fine Chemicals Synthesis:
2,6-difluorobenzene-1-carbothioamide is an important intermediate in the synthesis of various fine chemicals. Its versatility and reactivity make it a valuable component in the creation of specialty chemicals for diverse applications.

Upstream product

• 1897-52-5 2,6 difluorobenzonitrile 
• 18063-03-1 2,6-difluorobenzamide 

Downstream Products

• 1187056-38-7 ethyl 2-(2,6-difluorophenyl)-1,3-thiazole-4-carboxylate 
• 1017452-64-0 2-(2,6-difluorophenyl)-1,3-thiazole-4-carboxylic acid 
• 1187056-42-3 2-(2,6-difluorophenyl)thiazole-4-carboxylic acid 
• 1187053-64-0 (S)-N-(4-(3-aminopiperidin-1-yl)pyridin-3-yl)-2-(2,6-difluorophenyl)thiazole-4-carboxamide hydrochloride 
• 1187056-41-2 ethyl 5-amino-2-(2,6-difluorophenyl)thiazole-4-carboxylate 
• 1187056-40-1 5-amino-2-(2,6-difluorophenyl)-1,3-thiazole-4-carboxylic acid 
• 1187055-11-3 (S)-N-(4-(3-aminopiperidin-1-yl)pyridin-3-yl)-2-(2,6-difluorophenyl)thiazole-4-carboxamide 

Relevant academic research and scientific papers

Optimization of Pan-Pim Kinase Activity and Oral Bioavailability Leading to Diaminopyrazole (GDC-0339) for the Treatment of Multiple Myeloma

Pim kinases have been targets of interest for a number of therapeutic areas. Evidence of durable single-agent efficacy in human clinical trials validated Pim kinase inhibition as a promising therapeutic approach for multiple myeloma patients. Here, we report the compound optimization leading to GDC-0339 (16), a potent, orally bioavailable, and well tolerated pan-Pim kinase inhibitor that proved efficacious in RPMI8226 and MM.1S human multiple myeloma xenograft mouse models and has been evaluated as an early development candidate.

Identification of N-(4-((1R,3S,5S)-3-amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide (PIM447), a potent and selective proviral insertion site of Moloney murine leukemia (PIM) 1, 2, and 3 kinase inhibitor in clinical trials for hematological malignancies

Pan proviral insertion site of Moloney murine leukemia (PIM) 1, 2, and 3 kinase inhibitors have recently begun to be tested in humans to assess whether pan PIM kinase inhibition may provide benefit to cancer patients. Herein, the synthesis, in vitro activity, in vivo activity in an acute myeloid leukemia xenograft model, and preclinical profile of the potent and selective pan PIM kinase inhibitor compound 8 (PIM447) are described. Starting from the reported aminopiperidyl pan PIM kinase inhibitor compound 3, a strategy to improve the microsomal stability was pursued resulting in the identification of potent aminocyclohexyl pan PIM inhibitors with high metabolic stability. From this aminocyclohexyl series, compound 8 entered the clinic in 2012 in multiple myeloma patients and is currently in several phase 1 trials of cancer patients with hematological malignancies.

CYCLIC ETHER COMPOUNDS USEFUL AS KINASE INHIBITORS

The present invention provides a compound of Formula (I): and pharmaceutically acceptable salts thereof, as further described herein. Also provided are formulations comprising compounds of formula I, and a method to use such compounds for treating a disease or condition mediated by Provirus Integration of Maloney Maloney Kinase (PIM Kinase), GSK3, PKC, KDR, PDGFRa, FGFR3, FLT3, or cABL.

Pim kinase inhibitors and methods of their use

The present invention relates to new compounds of Formulas I and II, their tautomers, stereoisomers and polymorphs, and pharmaceutically acceptable salts, esters, metabolites or prodrugs thereof, compositions of the new compounds together with pharmaceutically acceptable carriers, and uses of the new compounds, either alone or in combination with at least one additional therapeutic agent, in the inhibition of Pim kinase activity and/or the prophylaxis or treatment of cancer.

PIM KINASE INHIBITORS AND METHODS OF THEIR USE

The present invention relates to new compounds of Formulas (I) and (II), their tautomers, stereoisomers and polymorphs, and pharmaceutically acceptable salts, esters, metabolites or prodrugs thereof, compositions of the new compounds together with pharmac

A mild and versatile synthesis of thioamides

Aliphatic and aromatic nitriles react with thioacetic acid in the presence of calcium hydride to give the corresponding thioamides in good to excellent yields. The examples studied include haloaryl nitriles in which the halogen is facile towards SNAr reactions under other conditions. Georg Thieme Verlag Stuttgart.

3-(substituted phenyl)-5-(substituted heterocyclyl)-1,2,4-triazole compounds

3-(Substituted phenyl)-5-(substituted heterocyclyl)-1,2,4-triazole compounds are useful as insecticides and acaricides. New synthetic procedures and intermediates for preparing the compounds, pesticide compositions containing the compounds, and methods of controlling insects and mites using the compounds are also provided.

3-(substituted phenyl)-5-(thienyl or furyl)-1, 2, 4-triazole compounds

3-(Substituted phenyl)-5-(thienyl or furyl)-1,2,4-triazole compounds are useful as insecticides and acaricides. New synthetic procedures and intermediates for preparing the compounds, pesticide compositions containing the compounds, and methods of controlling insects and mites using the compounds are also provided.