1187236-18-5

Usage

Uses

Used in Pharmaceutical Industry:
Imidazo[1,2-a]pyridine-2-carboxylic acid, 7-bromo-, ethyl ester is used as a chemical intermediate for the synthesis of various biologically active compounds. Its role in the creation of new drugs and therapeutic agents is significant due to its potential as an anti-cancer and anti-inflammatory agent.
Used in Cancer Treatment:
In the field of oncology, Imidazo[1,2-a]pyridine-2-carboxylic acid, 7-bromo-, ethyl ester is used as a potential anti-cancer agent. It is being explored for its ability to target and treat various types of cancer, leveraging its inherent properties to combat tumor growth and proliferation.
Used in Anti-Inflammatory Applications:
Beyond its anti-cancer potential, Imidazo[1,2-a]pyridine-2-carboxylic acid, 7-bromo-, ethyl ester is also considered for its anti-inflammatory properties. It may be utilized in the development of treatments aimed at reducing inflammation, which is a common factor in many diseases and conditions.
Synthesis Method:
Imidazo[1,2-a]pyridine-2-carboxylic acid, 7-bromo-, ethyl ester is typically synthesized through the esterification of imidazo[1,2-a]pyridine-2-carboxylic acid with ethanol, facilitated by a suitable catalyst. This method allows for the production of the compound in a controlled and efficient manner, ensuring its availability for use in pharmaceutical applications.

Upstream product

• 84249-14-9 2-amino-4-bromopyridine 
• 70-23-5 ethyl Bromopyruvate 

Downstream Products

• 1187236-21-0 (7-bromoimidazo[1,2-a]pyridin-2-yl)methanol 
• 1019023-07-4 7-bromo-2-chloromethylimidazo[1,2-a]pyridine 
• 1454907-26-6 (4S,5R)-4-fluoromethyl-5-{4-[2-(methanesulfonylaminomethyl)imidazo[1,2-a]pyridin-7-yl]phenyl}-2,2-dimethyloxazolidine-3-carboxylic acid tert-butyl ester 
• 1454907-27-7 N-{7-[4-((1R,2S)-2-amino-3-fluoro-1-hydroxypropyl)phenyl]imidazo[1,2-a]pyridin-2-ylmethyl}methanesulfonamide 
• 1454904-55-2 2,2-difluoro-N-((1S,2R)-1-fluoromethyl-2-hydroxy-2-{4-[2-(methanesulfonylaminomethyl)imidazo[1,2-a]pyridin-7-yl]phenyl}ethyl)acetamide 
• 1541189-93-8 C₂₅H₃₀N₄O₄Si 
• 1541187-87-4 morpholin-4-yl-{7-[4-(2H-pyrazol-3-yl)phenoxy]imidazo[1,2-a]pyridin-2-yl}methanone 
• 1541189-94-9 C₁₉H₁₆N₄O₃ 
• 1541189-95-0 C₁₇H₁₂N₄O₃ 
• 1202179-45-0 7-bromo-2-(difluoromethyl)imidazo[1,2-a]pyridine 

Relevant academic research and scientific papers

TLR2 MODULATOR COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF

The present disclosure relates to compounds which modulate the activity of Toll-like receptor (TLR) proteins, including agonists or activators, partial agonists, and antagonists. Of particular interest of compounds that modulate the activity of TLR2, as well as methods of using such compounds to treat cancer and other disorders associated with a TLR2 pathway.

SUBSTITUTED HETEROARYL COMPOUNDS AND METHODS OF USE

The present invention provides novel heteroaryl compounds, pharmaceutical acceptable salts and formulations thereof. They are useful in preventing, managing, treating or lessening the severity of a protein kinase-mediated disease. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of protein kinase-mediated disease.

Substituted heteroaryl compounds and compositions and uses thereof (by machine translation)

The invention discloses substituted heteroaryl compounds and compositions thereof and their use. The compounds of formula (I) compound or type shown in (I) a compound represented by stereo isomers, tautomers, nitrogen oxide, solvate, metabolite, pharmaceutically acceptable salt or its prodrug. The invention also provides a pharmaceutical composition, the compounds and pharmaceutical compositions can be regulated protein kinase, particularly Aurora kinase and JAK kinase activity, for the prevention, treatment, treatment and reduce protein kinase, in particular JAK kinase activity mediated diseases or disorders. (by machine translation)

INHIBITORS OF LEUKOTRIENE PRODUCTION

The present invention relates to compounds of formula (I): or a pharmaceutically acceptable salt thereof, wherein A1, A2, L1 and B are as defined herein. The compounds of formula (I) are useful as inhibitors of leukotriene A4 hydrolase (LTA4H) and treating LTA4H related disorders. The present invention also relates to pharmaceutical compositions comprising the compounds of formula (I), methods of using these com-pounds in the treatment of various diseases and disorders, and processes for preparing these compounds.

PHENICOL ANTIBACTERIALS

The present invention provides novel phenicol derivatives, their use for the treatment of infections in mammals, pharmaceutical composition containing these novel compounds, and methods for the preparation of these compounds.

N-AZABICYCLIC CARBOXAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF

This disclosure relates to compounds of formula (I): wherein X1, X2, X3, X4, n, Y, W, and A are as defined in the disclosure, or a salt thereof, or a hydrate or solvate thereof, and to processes for the preparation of these compounds and the therapeutic use thereof.