118737-62-5

Basic information

• Product Name: 2,4-DIFLUOROBENZOIC ACID HYDRAZIDE
• Synonyms: BUTTPARK 35\03-74;2,4-DIFLUOROBENZOIC ACID HYDRAZIDE;2,4-DIFLUOROBENZHYDRAZIDE;2,4-DIFLUOROBENZOHYDRAZIDE;2,4-DIFLUOROBENZOIC HYDRAZIDE;2,4-Difluorobenzoic acid hydrazide 97%;2,4-Difluorobenzoicacidhydrazide97%;2,4-difluorobenzene-1-carbohydrazide
• CAS NO: 118737-62-5
• Molecular Formula: C7H6F2N2O
• Molecular Weight: 172.13
• Product Categories: Fluorine Compounds
• Mol File: 118737-62-5.mol

Chemical Properties

• Melting Point: 141 °C
• Appearance: /
• Density: 1.373 g/cm³
• Refractive Index: 1.53
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 11.44±0.10(Predicted)
• CAS DataBase Reference: 2,4-DIFLUOROBENZOIC ACID HYDRAZIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-DIFLUOROBENZOIC ACID HYDRAZIDE(118737-62-5)
• EPA Substance Registry System: 2,4-DIFLUOROBENZOIC ACID HYDRAZIDE(118737-62-5)

Safety Data

• Hazard Codes: Xi
• Statements: 20/21/22
• Safety Statements: 22-36/37/39
• Hazardous Substances Data: 118737-62-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2,4-DIFLUOROBENZOIC ACID HYDRAZIDE is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to form new compounds with potential therapeutic properties. Its unique structure allows for the development of drugs targeting specific biological pathways, contributing to the advancement of medicine.
Used in Agrochemical Industry:
In the agrochemical sector, 2,4-DIFLUOROBENZOIC ACID HYDRAZIDE is used as a precursor in the production of agrochemicals, such as pesticides and herbicides. Its incorporation into these products enhances their effectiveness in controlling pests and weeds, thereby improving crop yields and ensuring food security.
Used in Organic Synthesis:
2,4-DIFLUOROBENZOIC ACID HYDRAZIDE is utilized as a building block in organic synthesis, allowing chemists to create a wide range of compounds with diverse applications. Its reactivity and structural features make it a versatile component in the synthesis of various organic compounds, including pharmaceuticals, agrochemicals, and other specialty chemicals.
Used as a Reagent in Chemical Reactions:
2,4-DIFLUOROBENZOIC ACID HYDRAZIDE also serves as a reagent in various chemical reactions, facilitating the formation of new chemical entities. Its ability to participate in a range of reactions, such as condensation, substitution, and rearrangement, makes it a valuable tool in the synthesis of complex organic molecules.
It is important to handle 2,4-DIFLUOROBENZOIC ACID HYDRAZIDE with care, as it may pose hazards to human health and the environment. Proper safety measures and disposal methods should be followed to minimize any potential risks associated with its use.

InChI:InChI=1/C7H6F2N2O/c8-4-1-2-5(6(9)3-4)7(12)11-10/h1-3H,10H2,(H,11,12)

Upstream product

• 72482-64-5 2,4-difluorobenzoyl chloride 
• 108928-00-3 ethyl 2,4-di-fluorobenzoate 
• 1583-58-0 2,4-difluoro-benzoic acid 
• 106614-28-2 methyl 2,4-difluorobenzoate 

Downstream Products

• 1356585-72-2 C₁₀H₈F₂N₂O₃S 
• 1257543-46-6 C₁₄H₁₀ClF₂N₃OS 
• 1254071-39-0 7-{[2-chloro-3-(trifluoromethyl)phenyl]carbonyl}-3-(2,4-difluorophenyl)-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazine 
• 329974-19-8 2,4-difluorobenzoic acid (1-amino-2-benzenesulfonylethylidene)hydrazide 

Relevant articles and documents

Design, synthesis, and evaluation of N-benzylpyrrolidine and 1,3,4-oxadiazole as multitargeted hybrids for the treatment of Alzheimer's disease

Novel N-Benzylpyrrolidine hybrids were designed, synthesized, and tested against multiple in-vitro and in-vivo parameters. Among all the synthesized molecules, 8f and 12f showed extensive inhibition against beta-secretase-1 (hBACE-1), human acetylcholinesterase (hAChE) & human butyrylcholinesterase (hBuChE). These molecules are also endowed with significant AChE-peripheral anionic site (PAS) binding capability, blood-brain barrier permeability, potential disassembly of Aβ aggregates along with neuroprotection ability on SHSY-5Y cell lines. Results of the Y-Maze and Morris water maze test concluded that compounds 8f and 12f ameliorated cognitive dysfunction induced by scopolamine and Aβ. The ex-vivo activity was executed on rat's brain homogenate indicating a reduction in AChE level and oxidative stress. The pharmacokinetic investigation ascertained considerable oral absorption profile of the lead 12f. The results of the in silico docking studies and molecular dynamics simulations demonstrated stable interactions of compounds 8f and 12f with the target residues of hAChE, hBuChE and hBACE-1.

Antibacterial and Antiviral Activities of 1,3,4-Oxadiazole Thioether 4H-Chromen-4-one Derivatives

Various 1,3,4-oxadiazole thioether 4H-chromen-4-one derivatives were conceived. The title compounds demonstrated striking inhibitory effects againstXac,Psa, andXoo. EC50data exhibited that A8 (19.7 μg/mL) had better antibacterial activity againstXoothan myricetin, BT, and TC. Simultaneously, the mechanism of action of A8 had been verified by SEM. The results of anti-tobacco mosaic virus indicated that A9 had the bestin vivoantiviral effect compared with ningnanmycin. From the data of MST, it could be seen that A9 (0.003 ± 0.001 μmol/L) exhibited a strong binding capacity, which was far superior to ningnanmycin (2.726 ± 1.301 μmol/L). This study shows that the 1,3,4-oxadiazole thioether 4H-chromen-4-one derivatives may become agricultural drugs with great potential.

Novel Molecular Hybrids of N-Benzylpiperidine and 1,3,4-Oxadiazole as Multitargeted Therapeutics to Treat Alzheimer's Disease

Multitargeted hybrids of N-benzylpiperidine and substituted 5-phenyl-1,3,4-oxadiazoles were designed, synthesized, and evaluated against Alzheimer's disease (AD). Tested compounds exhibited moderate to excellent inhibition against human acetylcholinesterase (hAChE), butyrylcholinesterase (hBChE), and beta-secretase-1 (hBACE-1). The potential leads 6g and 10f exhibited balanced inhibitory profiles against all the targets, with a substantial displacement of propidium iodide from the peripheral anionic site of hAChE. Hybrids 6g and 10f also elicited favorable permeation across the blood-brain barrier and were devoid of neurotoxic liability toward SH-SY5Y neuroblastoma cells. Both leads remarkably disassembled Aβ aggregation in thioflavin T-based self- and AChE-induced experiments. Compounds 6g and 10f ameliorated scopolamine-induced cognitive dysfunctions in the Y-maze test. The ex vivo studies of rat brain homogenates established the reduced AChE levels and antioxidant activity of both compounds. Compound 6g also elicited noteworthy improvement in Aβ-induced cognitive dysfunctions in the Morris water maze test with downregulation in the expression of Aβ and BACE-1 proteins corroborated by Western blot and immunohistochemical analysis. The pharmacokinetic study showed excellent oral absorption characteristics of compound 6g. The in silico molecular docking and dynamics simulation studies of lead compounds affirmed their consensual binding interactions with PAS-AChE and aspartate dyad of BACE-1.

Tirfluoromethylpyridine oxadiazoles (ether)derivative and application thereof

The invention discloses an application of a tirfluoromethylpyridine oxadiazole (ether)derivative in a pesticide. A structure is shown as a general formula I, a compound shown in the general formula Ihas good insecticidal activity, and can be used for controlling insects such as diamondback moth and armyworm. The compound has excellent control effect for insects such as diamondback moth and armyworm, and also has control effect for the insects having resistance to the traditional pesticides, in addition, introduction of fluorine-containing groups such as tirfluoromethylpyridine and oxadiazoleas well as heterocyclic ring can enhance a rate for forming hydrogen bond effect between a compound and a target, and the activity of the compound is increased.

SELECTIVE HDAC6 INHIBITORS

The present invention relates to novel benzohydroxamic compounds of formula (I) and (II) and pharmaceutically acceptable salts, isomers and prodrugs thereof, exhibiting a high selective inhibitory activity against histone deacetylase 6 (HDAC6) enzyme.

Inhibition of tobacco bacterial wilt with sulfone derivatives containing an 1,3,4-oxadiazole moiety

A series of new sulfone compounds containing the 1,3,4-oxadiazole moiety were designed and synthesized. Their structures were identified by 1H and 13C nuclear magnetic resonance and elemental analyses. Antibacterial bioassays indicated that most compounds exhibited promising in vitro antibacterial bioactivities against tobacco bacterial wilt at 200 μg/mL. The relationship between structure and antibacterial activity was also discussed. Among the title compounds, 5′c, 5′h, 5′i, and 5′j could inhibit mycelia growth of Ralstonia solanacearum in vitro by approximately 50% (EC50) at 39.8, 60.3, 47.9, and 32.1 μg/mL, respectively. Among them, compound 5′j was identified as the most promising candidate due to its stronger effect than that of Kocide 3000 [Cu(OH)2] within the same concentration range. Field trials demonstrated that the control effect of compound 5′j against tobacco bacterial wilt was better than that of the commercial bactericide Saisentong. For the first time, the present work demonstrated that sulfone derivatives containing 1,3,4-oxadiazole can be used to develop potential bactericides for plants.