2,4-Difluorobenzohydrazide

Base Information

• Chemical Name: 2,4-Difluorobenzohydrazide
• CAS No.: 118737-62-5
• Molecular Formula: C₇H₆F₂N₂O
• Molecular Weight: 172.134
• Hs Code.: 2928000090
• European Community (EC) Number: 630-241-2
• DSSTox Substance ID: DTXSID00371707
• Wikidata: Q72462602
• Mol file: 118737-62-5.mol

Synonyms:2,4-difluorobenzohydrazide;118737-62-5;2,4-Difluorobenzoic acid hydrazide;2,4-difluorobenzhydrazide;2,4-DIFLUOROBENZOYL HYDRAZINE;2,4-difluorobenzoic hydrazide;Benzoic acid, 2,4-difluoro-, hydrazide;SCHEMBL108531;DTXSID00371707;FGBCAURJSKHDGC-UHFFFAOYSA-N;MFCD00173685;AKOS000140187;AC-7809;AS-9371;CS-0207490;FT-0610088;E78627;EN300-1264057;A804085;2,4-Difluorobenzoic hydrazide , 2,4-Difluorobenzhydrazide

Chemical Property of 2,4-Difluorobenzohydrazide

Chemical Property:

• Melting Point: 141 °C
• Refractive Index: 1.53
• PKA: 11.44±0.10(Predicted)
• PSA: 55.12000
• Density: 1.373 g/cm³
• LogP: 1.65950
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• XLogP3: 0.7
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 172.04481914
• Heavy Atom Count: 12
• Complexity: 177

Purity/Quality:

98%min ^*data from raw suppliers

2,4-Difluorobenzoicacidhydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 20/21/22
• Safety Statements: 22-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(C=C1F)F)C(=O)NN

Technology Process of 2,4-Difluorobenzohydrazide

There total 5 articles about 2,4-Difluorobenzohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,4-difluorobenzoyl chloride (72482-64-5) → 2,4-difluorobenzoic acid hydrazide (118737-62-5)

Guidance literature:

2,4-difluorobenzoyl chloride; With t-butoxycarbonylhydrazine; sodium hydrogencarbonate; In acetonitrile; at 20 ℃; for 3h;

With trifluoroacetic acid; for 3h;

Reference yield:

ethyl 2,4-di-fluorobenzoate (108928-00-3) → 2,4-difluorobenzoic acid hydrazide (118737-62-5)

Guidance literature:

With hydrazine hydrate; In ethanol; Heating;

Reference yield:

2,4-difluoro-benzoic acid (1583-58-0) → 2,4-difluorobenzoic acid hydrazide (118737-62-5)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid

2: hydrazine hydrate / methanol

With sulfuric acid; hydrazine hydrate; In methanol;

DOI:10.1021/jf203772d

upstream raw materials:

methyl 2,4-difluorobenzoate

2,4-difluoro-benzoic acid

ethyl 2,4-di-fluorobenzoate

2,4-difluorobenzoyl chloride

Downstream raw materials:

C₁₀H₈F₂N₂O₃S

C₁₄H₁₀ClF₂N₃OS

7-{[2-chloro-3-(trifluoromethyl)phenyl]carbonyl}-3-(2,4-difluorophenyl)-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazine

2,4-difluorobenzoic acid (1-amino-2-benzenesulfonylethylidene)hydrazide

Refernces

• 1、 Cao, Xiao,Liu, Fang,Liu, Liwei,Liu, Tingting,Peng, Feng,Wang, Qifan,Xie, Chengwei,Xue, Wei,Yang, Jinsong. "Antibacterial and Antiviral Activities of 1,3,4-Oxadiazole Thioether 4H-Chromen-4-one Derivatives". . p. 11085 - 11094. Retrieved 2021/10/01.
• 2、 -. "Tirfluoromethylpyridine oxadiazoles (ether)derivative and application thereof". . . Retrieved 2018/07/30.