118738-91-3Relevant articles and documents
4 - (4 - ((9H - purine - 6 - yl) thio) phenyl) thiazolyl - 2 - amine derivative and its preparation and use
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, (2017/08/04)
The invention belongs to the field of chemical medicine and particularly relates to a 4-(4-((9H-purine-6-base)sulphur)phenyl)thiazolyl-2-amine derivative and a preparation method and application thereof. The structure of the 4-(4-((9H-purine-6-base)sulphur)phenyl)thiazolyl-2-amine derivative is shown in the formula I. The preparation method of the 4-(4-((9H-purine-6-base)sulphur)phenyl)thiazolyl-2-amine derivative and the application of the 4-(4-((9H-purine-6-base)sulphur)phenyl)thiazolyl-2-amine derivative in preparation of medicine for treating tumors are further provided. The synthetic route is short, reaction conditions are simple, the yield is high, and derivatization is easy. A series of compounds have good anti-tumor activity and low toxicity. A new choice is provided for preparation of the anti-tumor medicine. See the formula in the specification.