83759-88-0

Usage

Uses

Used in Pharmaceutical Industry:
Ethanone, 1-(4-amino-2,6-dimethylphenyl)(9CI) is used as a chemical intermediate for the synthesis of various pharmaceutical compounds. Its unique structure allows it to serve as a building block in the development of new drugs, potentially contributing to the creation of novel therapeutic agents.
Used in Research Applications:
In the field of scientific research, Ethanone, 1-(4-amino-2,6-dimethylphenyl)(9CI) is utilized as a research chemical. Its distinctive properties make it a valuable tool for studying chemical reactions and mechanisms, as well as for exploring its potential interactions with biological systems.
Used in Chemical Synthesis:
Ethanone, 1-(4-amino-2,6-dimethylphenyl)(9CI) is employed as a reagent in various chemical synthesis processes. Its reactive functional groups enable it to participate in a range of chemical transformations, facilitating the production of diverse chemical entities for various applications.
Used in Analytical Chemistry:
Ethanone, 1-(4-amino-2,6-dimethylphenyl)(9CI) can also be used in analytical chemistry as a reference material or standard for the development and validation of analytical methods. Its distinct chemical properties make it suitable for calibrating instruments and ensuring the accuracy of measurements in various analytical techniques.

Upstream product

• 100923-73-7 N-(4-acetyl-3,5-dimethylphenyl)acetamide 
• 108-69-0 3,5-dimethylaminoaniline 
• 75-36-5 acetyl chloride 
• 2050-45-5 N-acetyl-3,5-dimethylaniline 

Downstream Products

• 53379-63-8 1-acetyl-4-bromo-2,6-dimethylbenzene 
• 35887-71-9 1-(4-chloro-2,6-dimethylphenyl)ethanone 
• 114820-21-2 1-acetyl-2,6-dimethylbenzene-4-diazonium tetrafluoroborate 
• 91060-92-3 1-(4-hydroxy-2,6-dimethylphenyl)ethanone 
• 23600-98-8 (Acetyl-4-dimethyl-3.5-phenyl)-(methoxy-4'-phenyl)-amin 
• 23699-64-1 (Acetyl-4-dimethyl-3.5-phenyl)-(methyl-2'-phenyl)-amin 
• 23601-00-5 (Acetyl-4-dimethyl-3.5-phenyl)-(trimethyl-2'.4'.6'-phenyl)-amin 
• 23600-99-9 (Acetyl-4-dimethyl-3.5-phenyl)-(dimethyl-2'.5'-phenyl)-amin 
• 23600-96-6 (Acetyl-4-dimethyl-3.5-phenyl)-(carboxyl-2'-phenyl)-amin 
• 60999-76-0 1-(4-methoxy-2,6-dimethylphenyl)ethanone 
• 114820-12-1 1-acetyl-4-fluoro-2,6-dimethylbenzene 
• 118738-91-3 1-(4-iodo-2,6-dimethylphenyl)ethanone 
• 23600-97-7 1-(2,6-dimethyl-4-(phenylamino)phenyl)ethanone 
• 1203605-34-8 (4-acetyl-3,5-dimethyl-phenyl)-carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

Aerobic intramolecular carbon-hydrogen bond oxidation promoted by Cu(i) complexes

The oxidation of C-H bonds by copper centres in enzymes with molecular oxygen takes place in nature under ambient conditions. Herein we report a similar transformation in which under ambient pressure and temperature (1 atm, 25 °C) the complex TpMsCu(THF)

4 - (4 - ((9H - purine - 6 - yl) thio) phenyl) thiazolyl - 2 - amine derivative and its preparation and use

The invention belongs to the field of chemical medicine and particularly relates to a 4-(4-((9H-purine-6-base)sulphur)phenyl)thiazolyl-2-amine derivative and a preparation method and application thereof. The structure of the 4-(4-((9H-purine-6-base)sulphur)phenyl)thiazolyl-2-amine derivative is shown in the formula I. The preparation method of the 4-(4-((9H-purine-6-base)sulphur)phenyl)thiazolyl-2-amine derivative and the application of the 4-(4-((9H-purine-6-base)sulphur)phenyl)thiazolyl-2-amine derivative in preparation of medicine for treating tumors are further provided. The synthetic route is short, reaction conditions are simple, the yield is high, and derivatization is easy. A series of compounds have good anti-tumor activity and low toxicity. A new choice is provided for preparation of the anti-tumor medicine. See the formula in the specification.

Synthesis and biological evaluation of N-(4-phenylthiazol-2-yl)cinnamamide derivatives as novel potential anti-tumor agents

In this study, a series of novel N-(4-phenylthiazol-2-yl)cinnamamide derivatives (7a-8n) were synthesized and evaluated for their anti-proliferative activities in vitro by MTT assay and a possible antitumor mechanism was also explored. SAR analysis showed that steric effects played an important role on the anti-tumor activity. The most potent analogue 8f showed excellent inhibitions on the K562, Bel7402, A549 and Jurkat cells ranging from sub-micromolar to nanomolar concentration. Compound 8f inhibited Jurkat cells with an IC50 value of 0.035 μM with no apparent toxicity in different non-cancerous cells. Furthermore, it was suggested that the possible mechanism of 8f might be associated with inducing cancer cell apoptosis following flow cytometer analysis and Hoechst 33358 staining assays.