1187560-75-3

Upstream product

• 402-43-7 p-trifluoromethylphenyl bromide 
• 5700-74-3 (S)-N-(ethoxycarbonyl)proline 
• 147-85-3 L-proline 
• 77581-28-3 (S)-proline-N-ethyl carbamate methyl ester 

Downstream Products

• 131180-65-9 (S)-α,α-Bis(4-(trifluoromethyl)phenyl)-2-pyrrolidinemethanol 

Relevant academic research and scientific papers

Towards a General Understanding of Carbonyl-Stabilised Ammonium Ylide-Mediated Epoxidation Reactions

The key factors for carbonyl-stabilised ammonium ylide-mediated epoxidation reactions were systematically investigated by experimental and computational means and the hereby obtained energy profiles provide explanations for the observed experimental results. In addition, we were able to identify the first tertiary amine-based chiral auxiliary that allows for high enantioselectivities and high yields for such epoxidation reactions.

Efficient separation of a trifluoromethyl substituted organocatalyst: Just add water

A practical, cost-saving tagging approach is developed which takes advantage of the hydrophobicity of trifluoromethyl groups, exemplified by the application and recovery of a CBS precatalyst using tuned aqueous-organic media with minimum 50% water content