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Usage

Uses

Used in Pharmaceutical Industry:
(R)-hexahydro-1H-pyrido[1,2-a]pyrazin-4(6H)-one is used as a key intermediate for the development of novel drug molecules for various therapeutic purposes. Its role in the biosynthetic pathway of hydroxyproline makes it a valuable compound for creating treatments that target tissue repair, wound healing, and anti-aging.
Used in Cosmetic Industry:
In the cosmetic industry, (R)-hexahydro-1H-pyrido[1,2-a]pyrazin-4(6H)-one is used as an ingredient to support the structure and function of connective tissues. Its presence in products can help improve skin elasticity and overall skin health, making it a sought-after component in anti-aging and skin repair formulations.
Used in Research and Development:
(R)-hexahydro-1H-pyrido[1,2-a]pyrazin-4(6H)-one is also utilized in research and development for its potential applications in creating new pharmaceutical compounds. Its role in the biosynthesis of hydroxyproline and its effects on connective tissues make it a promising candidate for further study and development in the medical and cosmetic fields.

Upstream product

• 139004-93-6 (S)-tert-butyl (piperidin-2-ylmethyl)carbamate 
• 683233-14-9 tert-butyl (2R)-2-(aminomethyl)piperidine-1-carboxylate 
• 1353975-00-4 (R)-benzyl ((1-(2-chloroacetyl)piperidin-2-yl)methyl)carbamate 
• 184044-09-5 (R)-benzyl (piperidin-2-ylmethyl)carbamate 
• 248914-26-3 (S)-2-tert-butoxycarbonyl-4-oxooctahydro-2H-pyrido[1,2-a]pyrazine 
• 3731-51-9 2-(Aminomethyl)pyridine 
• 100-70-9 2-Cyanopyridine 
• 62402-24-8 ethyl [(pyridin-2-ylmethyl)amino]acetate 
• 248914-23-0 tert-butyl ({(2S)-1-[(1R)-2-hydroxy-1-phenylethyl]piperidin-2-yl}methyl)carbamate 
• 248914-24-1 tert-butyl {[(2S)-1-(chloroacetyl)piperidin-2-yl]methyl}carbamate 
• 153918-98-0 (2R)-2-<(2S)-2-(aminomethyl)piperidin-1-yl>-2-phenylethanol 

Relevant academic research and scientific papers

COMPOUNDS THAT INHIBIT MCL-1 PROTEIN

Provided herein are myeloid cell leukemia 1 protein (Mcl-1) inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula (I), or a stereoisomer thereof; and pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the compounds. The compounds and compositions provided herein may be used, for example, in the treatment of diseases or conditions, such as cancer.

PYRIDAZINONE DERIVATIVES AS PARP INHIBITORS

The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts or tautomers thereof which are inhibitors of poly(ADP-ribose)polymerase (PARP) and thus useful for the treatment of cancer, inflammatory diseases, reperfusion injuries, ischaemic conditions, stroke, renal failure, cardiovascular diseases, vascular diseases other than cardiovascular diseases, diabetes mellitus, neurodegenerative diseases, retroviral infections, retinaldamage, skin senescence and UV-induced skin damage, and as chemo-or radiosensitizers for cancer treatment.

Asymmetric synthesis of octahydro-2H-pyrido[1,2-a]-pyrazines

A series of optically pure octahydro-2H-pyrido[1,2-a]pyrazines has been prepared from (-)-2-cyano-6-phenyloxazolopiperidine (4). 2H-Pyrido[1,2- a]pyrazin-3-(4H)-one (7) and octahydro-2H-pyrido[1,2-a]pyrazine (14) were obtained from diamino alcohol (5) by