1188-35-8

Upstream product

• 64-17-5 ethanol 
• 5238-65-3 butane-1,2,4-tricarbonitrile 
• 923-42-2 butane-1,2,4-tricarboxylic acid 
• 20498-91-3 butane-1,2,4-tricarboxylic acid-2-ethyl ester 
• 70600-48-5 butane-1,2,2,4-tetracarboxylic acid tetraethyl ester 
• 1119-85-3 1,4-dicyano-2-butene 
• 7209-00-9 diethyl 2-bromoglutarate 
• 167467-16-5 (+)(R)-3-carboxy-adipic acid 
• 13042-02-9 2-hexenedinitrile 
• 140-88-5 ethyl acrylate 
• 2832-14-6 triethyl 1,1,3-propanetricarboxylate 
• 101568-03-0 3-(methoxycarbonyl)hexanedioic acid 
• 1113-80-0 1,3,4-Tricarbonsaeure-triaethylester-5-oxo-hexan 
• 101777-46-2 4-cyano-butane-1,2,2-tricarboxylic acid triethyl ester 

Downstream Products

• 3033-53-2 2-methyl-3-oxo-cyclopentanecarboxylic acid 

Relevant academic research and scientific papers

SUBSTITUTED PYRIMIDINE COMPOUNDS AND METHODS OF USE AND MANUFACTURE

This invention provides substituted pyrimidine compounds that are useful in treating a patient having a disease or cancer. The compounds of this invention are useful as multi-enzyme antifolates selectively targeting the folate receptor (FR). Further, a me

CONTRAST AGENTS

The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds. More specifically the iodine containing compounds are chemical compounds containing an aliphatic central moiety containing amide functions allowing for the arrangement of three iodinated phenyl groups bound thereto. The invention also relates to the use of such diagnostic compositions as contrast agents in diagnostic imaging and in particular in X-ray imaging and to contrast media containing such compounds.

SYNTHESIS OF POLYFUNCTIONAL ALIPHATIC CARBONYL COMPOUNDS UNDER PHASE-TRANSFER CONDITIONS

We have studied mono- and dialkylation of malonic, acetoacetic, and cyanoacetic esters with esters of haloacetic and β-halopropionic acids and addition of the CH acids mentioned and their analogues to methyl and ethyl acrylate under phase-transfer catalysis conditions, and also deethoxycarbonylation of the obtained products.We have demonstrated for the first time the possibility of Dieckmann cyclization under phase-transfer catalysis conditions and have developed a simple method for the synthesis of 2,3-di(ethoxycarbonyl)cyclopentanone, a key intermediate in the synthesis of deoxyprostaglandins, by cyclization of triethyl 1,2,4-butanetricarboxylate.

PROSTANOIDS. VII. trans-2,3-DIETHOXYCARBONYLCYCLOPENTANONE IN THE SYNTHESIS OF PROSTAGLANDINS

2,3-Diethoxycarbonylcyclopentanone was synthesized from methyl 3-cyclohexenecarboxylate; its telomerization with 1,3-butadiene gave 2-(2,7-octadienyl)2,3-diethoxycarbonylcyclopentanone, which was then transformed into 2α-(2,7-octadienyl)-3β-(3α-hydroxy-1-trans-octenyl)-1α-cyclopentanol, i.e., an analog of 11-deoxyprostaglandin-F1α.The key synthon for the synthesis of 11-deoxy-α-homoprostaglandin-E1 was obtained from 2-(2,7-octadienyl)-3-ethoxycarbonylcyclopentanone.A new method was developed for the production of the γ-lactone of 5α-hydroxy-2β-(3-oxo-1-trans-octenyl)-1α-cyclopentaneacetic acid - a well-known synthon in the synthesis of 11-deoxyprostaglandin-E2.The method was based on the alkylation of 2,3-diethoxycarbonylcyclopentanone with allyl bromide.