118829-18-8Relevant articles and documents
Trifluoromethylquinolinecarboxylic acid derivative
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, (2008/06/13)
This invention relates to a 8-trifluoromethylquinolinecaboxylic acid derivative represented by the following formula (I): (wherein R1 represents a lower alkyl group, a halogeno-lower alkyl group or a cycloalkyl group, R2 represents a phenyl group which may be substituted by R0, a 5-membered or 6-membered aromatic heteromonocyclic ring group containing 1 or 2 hetero atoms selected from N, O and S, which may be substituted by R0, or an aromatic heterocyclic fused ring group in which the said aromatic heteromonocyclic ring group and a benzene ring are fused, R0 represents a group selected from a halogen, a lower alkyl, a fluorine-substituted lower alkyl, a lower alkoxy or a lower alkylthio, R3 represents hydrogen or a lower alkyl group, and m represents an integer of 2 or 3.) or a pharmaceutically acceptable salt thereof or an ester thereof.
New 8-(trifluoromethyl)-substituted quinolones. The benefits of the 8- fluoro group with reduced phototoxic risk
Sanchez,Bridges,Bucsh,Domagala,Gogliotti,Hagen,Heifetz,Joannides,Sesnie,Shapiro,Szotek
, p. 361 - 367 (2007/10/02)
A series of 8-(trifluoromethyl)-substituted quinolones has been prepared and evaluated for in vitro and in vivo antibacterial activity, and phototolerance in a mouse phototolerance assay. These analogues were compared to the corresponding series of 6,8-di
