1188414-02-9

Basic information

• Product Name: (Z)-5-(2-(4-methoxybenzyloxy)ethylidene)furan-2(5H)-one
• Synonyms: (Z)-5-(2-(4-methoxybenzyloxy)ethylidene)furan-2(5H)-one
• CAS NO: 1188414-02-9
• Molecular Weight: 246.263
• Mol File: 1188414-02-9.mol

Chemical Properties

• CAS DataBase Reference: (Z)-5-(2-(4-methoxybenzyloxy)ethylidene)furan-2(5H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: (Z)-5-(2-(4-methoxybenzyloxy)ethylidene)furan-2(5H)-one(1188414-02-9)
• EPA Substance Registry System: (Z)-5-(2-(4-methoxybenzyloxy)ethylidene)furan-2(5H)-one(1188414-02-9)

Safety Data

• Hazardous Substances Data: 1188414-02-9(Hazardous Substances Data)

Upstream product

• 6214-35-3 (Z)-3-iodoprop-2-enoic acid 
• 4039-83-2 3-(4-methoxybenzyloxy)propyne 

Relevant articles and documents

Copper-catalyzed preparation of γ-alkylidenebutenolides and isocoumarins under mild palladium-free conditions

A general and efficient copper(I)-catalyzed cross-coupling and heterocyclization reaction of terminal alkynes and β-iodo-α,β- unsaturated acid derivatives has been developed under very mild conditions. This method provides easy access from good to excellent yields of a variety of 5-ylidenebutenolides and 3-substituted isocoumarins with excellent regio- and stereoselectivity. This procedure does not require the use of any expensive supplementary additives, and is palladium-free.

Pd/C-Cu mediated direct and one-pot synthesis of γ-ylidene butenolides

10% Pd/C in combination with CuI, PPh3, and Et3N has been identified as an effective catalyst system for the coupling of (Z)-3-iodoacrylic acid with terminal alkynes in 1,4-dioxane leading to the one-pot synthesis of γ-ylidene butenolides. The methodology showed remarkable regio- and stereoselectivity as only the five-membered lactone ring products were formed with an exocyclic double bond possessing Z-geometry.