1189155-63-2

Basic information

• Product Name: (R)-2-(4-BROMOPHENYL)PYRROLIDINE
• Synonyms: (R)-2-(4-BROMOPHENYL)PYRROLIDINE;(2R)-2-(4-broMophenyl)pyrrolidine;(2R)-2-(4-BROMOPHENYL)PYRROLIDINE HCl;Pyrrolidine, 2-(4-bromophenyl)-, (2R)-
• CAS NO: 1189155-63-2
• Molecular Formula: C₁₀H₁₂BrN
• Molecular Weight: 226.11
• Mol File: 1189155-63-2.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 287℃
• Flash Point: 128℃
• Appearance: /
• Density: 1.369
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: (R)-2-(4-BROMOPHENYL)PYRROLIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2-(4-BROMOPHENYL)PYRROLIDINE(1189155-63-2)
• EPA Substance Registry System: (R)-2-(4-BROMOPHENYL)PYRROLIDINE(1189155-63-2)

Safety Data

• Hazardous Substances Data: 1189155-63-2(Hazardous Substances Data)

Usage

General Description

(R)-2-(4-Bromophenyl)pyrrolidine, also known as (R)-2-(4-bromophenyl)pyrrolidine hydrochloride, is a chemical compound with molecular formula C11H13BrN. It belongs to the category of organic compounds known as aryl bromides. Aryl bromides are compounds containing an aromatic system made up of a ring of atoms, one of which is a bromine atom. This chemical compound usually appears as a white crystalline powder, and is widely used in scientific research, particularly in the pharmaceutical field. It exhibits particular properties that have made it an essential ingredient in the synthesis of certain drugs or compounds used in medicine. It's crucial to handle it with precautionary measures as this chemical may cause serious health risks if it’s not appropriately managed.

Upstream product

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Relevant articles and documents

Enantioselective Direct Synthesis of Free Cyclic Amines via Intramolecular Reductive Amination

Chiral cyclic amines can be prepared via intramolecular reductive amination of N-Boc-protected amino ketones in a one-pot process. With the complex of iridium and f-spiroPhos as the catalyst, a range of N-Boc-protected amino ketones are smoothly transformed into chiral cyclic free amines in high yields and excellent enantioselectivities (up to 97% ee). Moreover, this method can also be successfully applied to the synthesis of a κ-opioid receptor selective antagonist, (S)-1.

Asymmetric synthesis of 2-substituted pyrrolidines by addition of Grignard reagents to γ-chlorinated N-tert-butanesulfinyl imine

A highly diastereoselective addition of various Grignard reagents to chiral γ-chlorinated N-tert-butanesulfinyl imine resulting in the formation of 2-substituted pyrrolidines is reported. This method is general and also efficient for the preparation of both enantiomers of 2-aryl, 2-alkyl and 2-vinyl substituted pyrrolidines in high yields.