118918-76-6

Basic information

• Product Name: (2S,5R)-2-phenyl-1-aza-3-oxabicyclo<3.3.0>octan-8-one
• Synonyms: (2S,5R)-2-phenyl-1-aza-3-oxabicyclo<3.3.0>octan-8-one
• CAS NO: 118918-76-6
• Molecular Weight: 203.241
• Mol File: 118918-76-6.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: (2S,5R)-2-phenyl-1-aza-3-oxabicyclo<3.3.0>octan-8-one(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,5R)-2-phenyl-1-aza-3-oxabicyclo<3.3.0>octan-8-one(118918-76-6)
• EPA Substance Registry System: (2S,5R)-2-phenyl-1-aza-3-oxabicyclo<3.3.0>octan-8-one(118918-76-6)

Safety Data

• Hazardous Substances Data: 118918-76-6(Hazardous Substances Data)

Usage

General Description

The chemical compound "(2S,5R)-2-phenyl-1-aza-3-oxabicyclo<3.3.0>octan-8-one" is a bicyclic ketone with a phenyl group attached to carbon 2. It has a molecular formula of C11H13NO2 and is a chiral molecule with S and R configurations at carbons 2 and 5, respectively. The compound belongs to the class of organic compounds known as oxabicyclo compounds, which have a bicyclo[3.3.0]octane skeleton containing an oxygen atom. This chemical may have potential applications in the pharmaceutical and chemical industries due to its unique structure and properties, although further research and testing would be needed to determine its specific uses.

Upstream product

• 6893-26-1 D-Glutamic acid 
• 64700-65-8 methyl (2R)-pyroglutamate 
• 68766-96-1 ethyl (R)-2-pyrrolidone-5-carboxylate 
• 13107-55-6 D-glutamic acid diethyl ester 
• 66673-40-3 (R)-5-hydroxymethylpyrrolidin-2-one 
• 100-52-7 benzaldehyde 
• 62400-75-3 pyroglutamol 

Downstream Products

• 1613043-71-2 (3S,6R,7aR)-5-oxo-3-phenylhexahydropyrrolo[1,2-c]oxazol-6-yl-methanesulfonate 
• 1601475-93-7 C₃₃H₄₄F₃N₃O₆ 
• 1000894-85-8 C₂₀H₂₆F₃NO₅ 
• 1000894-83-6 C₁₂H₂₁NO₃ 

Relevant articles and documents

Synthesis of [(3S,5R)-3-Hydroxy-5-methylpiperidin-1-yl](2-methylpyridin-3-yl)methanone

Abstract: There remain challenges for effectively synthesizing heterocycles containingboth piperidine and pyridine rings, mainly due to the inefficient syntheticprocess mostly requiring long reaction times. This paper reports a simple andefficient method

Evolution of the process for the preparation of a selective erbb vegf receptor inhibitor

An efficient synthetic route to the potent and selective ErbB VEGF receptor inhibitor, BMS-690514 (1) is described. Strategic modifications in both approach and procedure addressed several issues, which led to a safe, efficient, and economical process for the preparation of multi-kilogram quantities of 1. The convergent route involves alkylation of a suitably protected (3R,4R)-4-aminopiperidin-3-ol with the triethyl(alkyl)ammonium salt of a functionalized pyrrolotriazine 3a followed by deprotection to provide 1 as the crystalline free base. Georg Thieme Verlag Stuttgart - New York.

Efficient total synthesis of AI-77-B, a gastroprotective substance from Bacillus pumilus AI-77

First total synthesis of AI-77-B (1), a gastroprotective substance from Bacillus pumilus AI-77, was achieved in a stereoselective and convergent manner. In this synthesis, the dihydroisocoumarin part 2 was constructed in one step through 1,2-addition of the benzylic anion 17b to Boc-L-leucinal 7b. The hydroxy amino acid 4 was elaborated from (R)-glutamic acid in a highly stereoselective manner. Condensation of 2·HCl and 4, intramolecular Pinner reaction, followed by mild hydrolysis afforded AI-77-B (1).