1189350-86-4Relevant academic research and scientific papers
Cross-coupling reaction of organoalane reagents with 2-mercaptobenzo-5-membered heterocycles for efficient synthesis of benzo-5-membered heterocycle sulfides
Luo, Rui-Qiang,Guo, Shao Peng,Xiao, Hong-Liu,Li, Qing-Han
, (2021/12/03)
A highly efficient and simple route for the synthesis of benzo-5-membered heterocycles sulfides has been developed by the cross-coupling reaction of 2-mercaptobenzo-5-membered heterocycles with (hetero)arylaluminum reagents. Various benzo-5-membered heter
Divergent S- And C-Difluoromethylation of 2-Substituted Benzothiazoles
Wang, Xiu,Ye, Wenchao,Kong, Taige,Wang, Chenlu,Ni, Chuanfa,Hu, Jinbo
supporting information, p. 8554 - 8558 (2021/11/13)
Two unprecedented and complementary synthetic strategies for S- and C-difluoromethylation of 2-substituted benzothiazoles have been developed by taking advantage of the remarkably different reactivity of CF2H- and 2-PySO2CF2- nucleophiles. A variety of structurally diverse difluoromethyl 2-isocyanophenyl sulfides and 2-difluoromethylated benzothiazoles were synthesized with these two new synthetic protocols.
N-heterocyclic carbene copper(I) complex-catalyzed direct C-H thiolation of benzothiazoles
Inomata, Hiroshi,Toh, Ayumi,Mitsui, Takashi,Fukuzawa, Shin-Ichi
supporting information, p. 4729 - 4731 (2013/08/23)
N-heterocyclic carbene (NHC) copper(I) complexes based on imidazol-2-ylidene and 1,2,3-triazol-5-ylidene catalyzed the direct C-H thiolation of benzothiazoles and benzoxazoles with aryl and alkyl thiols to give 2-aryl and 2-alkylthiobenzothiazoles in moderate-to-good yields. The NHC copper(I) complex [(IPr)CuI] was the most effective catalyst for the reaction among the NHC-Cu(I) complexes examined in this study.
Rhodium-catalyzed phenylthiolation reaction of heteroaromatic compounds using α-(phenylthio)isobutyrophenone
Arisawa, Mieko,Toriyama, Fumihiko,Yamaguchi, Masahiko
, p. 2344 - 2347 (2011/05/16)
In the presence of catalytic amounts of RhH(PPh3)4 and 1,2-bis(diphenylphosphino)ethane (dppe), 1,3-benzothiazoles, 1,3-benzoxazoles, and benzothiophene reacted with α-(phenylthio) isobutyrophenone giving 2-phenylthio derivatives. Reactive monocyclic heteroaromatics, 1-methyl-1,2,3,4-tetrazole and 2-cyanothiophene were also converted into the 5-phenylthio derivatives. The use of an appropriate phenylthio transfer reagent is crucial for the efficient catalyzed conversion of heteroaromatic C-H bonds into C-S bonds.
Intra- and Intermodular C-S bond formation using a single catalytic system: First direct access to arylthiobenzothiazoles
Murru, Siva,Ghosh, Harisadhan,Sahoo, Santosh K.,Patel, Bhisma K.
supporting information; experimental part, p. 4254 - 4257 (2010/01/06)
We have for the first time developed two llgand-assisted Cu(I)-catalyzed sequential Intra- and intermolecular 5-arylations leading to the direct synthesis of arylthiobenzothlazoles In one pot without an Inert atmosphere. Low catalyst loading, inexpensive
Copper(I)-catalyzed cascade synthesis of 2-substituted 1,3-benzothiazoles: Direct access to benzothiazolones
Murru, Siva,Mondal, Pravat,Yella, Ramesh,Patel, Bhisma K.
experimental part, p. 5406 - 5413 (2010/02/28)
An efficient cascade process for the preparation of 2-substituted 1,3-benzothiazoles directly from 2-haloaryl isothiocyanates and O or S nucleophiles by a Cu-catalyzed, intramolecular, C-S bond formation has been developed. This cascade method is viable f
