2942-15-6

Basic information

• Product Name: 6-METHYLBENZOTHIAZOLE
• Synonyms: 6-METHYLBENZOTHIAZOLE;Benzothiazole,6-methyl-;Benzothiazole, 6-methyl- (7CI,8CI,9CI);6-Methyl-1,3-benzothiazole;6-Methylbenzo[d]thiazole;6-methylbenzthiazole;6-METHYLBENZOTHIAZOLE（WS201628）
• CAS NO: 2942-15-6
• Molecular Formula: C₈H₇NS
• Molecular Weight: 149.21
• Product Categories: BENZOTHIAZOLE
• Mol File: 2942-15-6.mol
• Article Data: 19

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 6-METHYLBENZOTHIAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-METHYLBENZOTHIAZOLE(2942-15-6)
• EPA Substance Registry System: 6-METHYLBENZOTHIAZOLE(2942-15-6)

Safety Data

• Hazardous Substances Data: 2942-15-6(Hazardous Substances Data)

Usage

Chemical Properties

liquid

Synthesis Reference(s)

The Journal of Organic Chemistry, 12, p. 718, 1947 DOI: 10.1021/jo01169a005

Upstream product

• 2268-79-3 6-methyl-1,3-benzothiazole-2(3H)-thione 
• 2536-91-6 6-methylbenzothiazol-2-ylamine 
• 29289-13-2 2-iodo-4-methylaniline 
• 67-68-5 dimethyl sulfoxide 
• 68-12-2 N,N-dimethyl-formamide 
• 23451-96-9 2-amino-5-methylthiophenol 
• 124-38-9 carbon dioxide 
• 20600-51-5 N-(6-methylbenzo[d]thiazol-2-yl)acetamide 
• 106-49-0 p-toluidine 
• 64-18-6 formic acid 
• 3507-18-4 6-methylbenzo[d]thiazole-2-carboxylic acid 
• 2268-79-3 2-mercapto-6-methylbenzothiazole 
• 99-97-8 Dimethyl-p-toluidine 

Downstream Products

• 3622-35-3 benzothiazole-6-carboxylic acid 
• 23451-96-9 2-amino-5-methylthiophenol 
• 10205-58-0 6-methyl-2-phenyl-1,3-benzothiazole 
• 1268700-09-9 (6-methylbenzo[d]thiazol-2-yl)(phenyl)methanone 
• 65490-80-4 2-(4-chlorophenyl)-6-methyl-1,3-benzothiazole 
• 63703-05-9 2,3-dibenzyl-6,6'-dimethyl-2,3-dihydro-[2,2']bibenzothiazolyl 
• 101084-51-9 benzothiazole-6-carboxamide 
• 188624-35-3 2-chloromethyl-6-methylbenzothiazole 
• 110722-47-9 2-bromomethyl-6-methylbenzothiazole 
• 31183-91-2 2-[(2-amino-5-methylphenyl)dithio]-4-methylphenylamine 
• 54469-51-1 1-(6-methyl-benzothiazol-2-yl)-ethanol 
• 63703-02-6 3-benzyl-6-methyl-benzothiazolium; bromide 
• 1199943-78-6 2-(4-methoxyphenoxy)-6-methyl-1,3-benzothiazole 
• 89059-12-1 3,6-dimethyl-benzothiazolium; iodide 

Relevant articles and documents

Iodine-promoted ring-opening methylation of benzothiazoles with dimethyl sulfite

A halogen-bond promoted ring-opening methylation of benzothiazoles has been developed using dimethyl sulphite as a methylating reagent in the presence of a base. This approach represents a simple and efficient synthesis ofN-methyl-N-(o-methylthio)phenyl amides, and features direct construction of both N-Me and S-Me bonds in a one-pot reaction through the decomposition of easily prepared benzothiazoles.

K2S as Sulfur Source and DMSO as Carbon Source for the Synthesis of 2-Unsubstituted Benzothiazoles

We describe a three-component reaction of o-iodoanilines with K2S and DMSO that provides 2-unsubstituted benzothiazoles in moderate to good isolated yields with good functional group tolerance. Electron-rich aromatic amines and o-phenylenediamines instead of o-iodoanilines provided 2-unsubstituted benzothiazoles and 2-unsubstituted benzimidazoles with and without K2S under similar conditions. Notably, DMSO plays three vital roles: carbon source, solvent, and oxidant.

Method for synthesizing benzothiazole by microwave radiation of benzothioamide compound in aqueous phase

The invention discloses a method for synthesizing benzothiazole by microwave radiation of a benzothioamide compound in an aqueous phase. The method includes the steps: adding the benzothioamide compound into the aqueous phase under microwave conditions; performing cyclization under alkaline conditions to generate the benzothiazole. The method for preparing the benzothiazole is environmentally friendly, simple and convenient in operation, safe, cheap and efficient. Compared with the prior art, the method is applicable to a lot of functional groups, high in yield, few in by-products, simple in operation, safe, low in cost and environmentally friendly.