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1189683-82-6

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1189683-82-6 Usage

Chemical Properties

Brown Oil

Uses

Synthetic intermediate of Ranitidine.

Check Digit Verification of cas no

The CAS Registry Mumber 1189683-82-6 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,8,9,6,8 and 3 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1189683-82:
(9*1)+(8*1)+(7*8)+(6*9)+(5*6)+(4*8)+(3*3)+(2*8)+(1*2)=216
216 % 10 = 6
So 1189683-82-6 is a valid CAS Registry Number.

1189683-82-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-[(Dimethyl-d6-amino)methyl]-2-furanmethanol

1.2 Other means of identification

Product number -
Other names [5-[[bis(trideuteriomethyl)amino]methyl]furan-2-yl]methanol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1189683-82-6 SDS

1189683-82-6Downstream Products

1189683-82-6Relevant articles and documents

Ranitidine - Investigations into the Root Cause for the Presence of N-Nitroso- N, N-dimethylamine in Ranitidine Hydrochloride Drug Substances and Associated Drug Products

King, Fiona J.,Searle, Andrew D.,Urquhart, Michael W.

, p. 2915 - 2926 (2020)

The presence of low levels of N-nitroso-N,N-dimethylamine (NDMA) in ranitidine hydrochloride drug products has been reported by regulatory agencies. GlaxoSmithKline undertook a root cause analysis to investigate this observation using contemporaneous, highly sensitive analytical methodologies. The root cause analysis suggested that the presence of NDMA results from a slow degradation of the ranitidine molecule. Analysis using suitably isotopically labeled ranitidine hydrochloride confirmed the formation of NDMA solely from an intermolecular reaction of ranitidine hydrochloride without involvement of impurities. Factors that influence the rate of degradation include heat, humidity, and the crystal morphology of ranitidine hydrochloride with the material exhibiting a columnar habit showing a slower rate of degradation.

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