118972-96-6

Basic information

• Product Name: 1-Acetyl-3-hydroxyazetidine
• Synonyms: 1-Acetyl-3-hydroxyazetidine;1-(3-Hydroxy-1-azetidinyl)-ethanone;1-(3-hydroxyazetidin-1-yl)ethan-1-one;1-(3-Hydroxyazetidin-1-yl)ethanone;1-acetyl-3-Azetidinol;1-(3-Hydroxyazetidin-1-yl)
• CAS NO: 118972-96-6
• Molecular Formula: C₅H₉NO₂
• Molecular Weight: 115.13046
• Mol File: 118972-96-6.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 275.912°C at 760 mmHg
• Flash Point: 120.668°C
• Appearance: /
• Density: 1.275g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.537
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 13.31±0.20(Predicted)
• CAS DataBase Reference: 1-Acetyl-3-hydroxyazetidine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Acetyl-3-hydroxyazetidine(118972-96-6)
• EPA Substance Registry System: 1-Acetyl-3-hydroxyazetidine(118972-96-6)

Safety Data

• Hazardous Substances Data: 118972-96-6(Hazardous Substances Data)

Usage

General Description

1-Acetyl-3-hydroxyazetidine is a chemical compound with the molecular formula C5H9NO2. It is a azetidine derivative, which is a type of saturated heterocyclic compound containing a four-membered ring with three carbon atoms and one nitrogen atom. 1-Acetyl-3-hydroxyazetidine is also known as 3-hydroxyazetidine-1-acetate, and it is used in organic synthesis as a building block for the preparation of various pharmaceutical compounds and natural products. It has potential applications in the development of new drugs and therapeutic agents due to its unique molecular structure and functional groups. Additionally, it has been studied for its anti-inflammatory and analgesic properties, making it a promising candidate for further research in the field of medicinal chemistry.

InChI:InChI=1/C5H9NO2/c1-4(7)6-2-5(8)3-6/h5,8H,2-3H2,1H3

Upstream product

• 45347-82-8 azetidine-3-ol 
• 75-36-5 acetyl chloride 
• 143329-27-5 N-acetyl-3-acetoxyazetidine 
• 79-22-1 methyl chloroformate 

Downstream Products

• 179894-05-4 N-acetylazetidin-3-one 
• 519188-47-7 1-[3-(trityloxy)-1-azetidinyl]-1-ethanone 

Relevant articles and documents

Acylative dealkylation of N-tert-butyl-3-substituted azetidines: Facile access to [1.1.0]azabicyclobutane, 3-hydroxyazetidinium hydrochloride, and 3-azetidinones

A novel acylative dealkylation of N-tert-butylazetidines and its application to the facile high-yield syntheses of [1.1.0]azabicyclobutane, 3-hydroxyazetidinium hydrochloride, and 3-azetidinones is described.

6,5-HETEROCYCLIC PROPARGYLIC ALCOHOL COMPOUNDS AND USES THEREFOR

The invention relates to novel compounds of Formula I: wherein A, Y, R1, R2 and the subscript b each has the meaning as described herein and compounds of Formula I, and stereoisomers, geometric isomers, tautomers, solvates, metabolites, isotopes, pharmaceutically acceptable salts, or prodrugs thereof. Compounds of Formula I and pharmaceutical compositions thereof are useful in the treatment of disease and disorders in which undesired or over-activation of NF-kB signaling is observed.

Preparation of 3-Oxo- and 3-Ethylideneazetidine Derivatives

The preparation of 3-azetidinones with different N-substituents and their transformation to 3-ethylideneazetidines has been studied in relation with a projected synthesis of 3-ethylideneazetidine-2-carboxylic acid (= polyoximic acid; 1).The stable crystal