1189732-52-2 Usage
Uses
Used in Pharmaceutical Industry:
N4-Acetylsulfapyridine-d4 is used as a research compound for studying the metabolism and pharmacokinetics of Sulfasalazine. It helps in understanding the mechanism of action and side effects of the drug, leading to the development of safer and more effective therapeutic agents.
Used in Drug Metabolism Studies:
N4-Acetylsulfapyridine-d4 is used as a labeled internal standard in liquid chromatography-mass spectrometry (LC-MS) and gas chromatography-mass spectrometry (GC-MS) analysis. It aids in the accurate quantification and identification of metabolites in biological samples, ensuring reliable and precise results.
Used in Toxicology Research:
N4-Acetylsulfapyridine-d4 is used as a tool compound in toxicology studies to investigate the toxic effects of Sulfasalazine and its metabolites. It helps in understanding the potential risks and safety concerns associated with the drug, contributing to the development of safer therapeutic alternatives.
Used in Drug Development:
N4-Acetylsulfapyridine-d4 is used as a reference compound in the development of new drugs with similar therapeutic effects but fewer side effects. It serves as a benchmark for comparing the efficacy and safety profiles of newly synthesized compounds, guiding the optimization of drug candidates.
Check Digit Verification of cas no
The CAS Registry Mumber 1189732-52-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,8,9,7,3 and 2 respectively; the second part has 2 digits, 5 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1189732-52:
(9*1)+(8*1)+(7*8)+(6*9)+(5*7)+(4*3)+(3*2)+(2*5)+(1*2)=192
192 % 10 = 2
So 1189732-52-2 is a valid CAS Registry Number.
1189732-52-2Relevant academic research and scientific papers
Stable isotope deuterium labeled sulfanilamide drug and preparation method thereof
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, (2018/04/26)
The invention belongs to the technical field of chemical synthesis, and specifically relates to a stable isotope deuterium labeled sulfanilamide drug and a preparation method thereof. The preparationmethod comprises the following steps: (1) subjecting benzene-d6 (I) to a nitratlon reaction so as to prepare deuterium labeled nitrobenzene-d5 (II); (2) reducing nitro of the deuterium labeled nitrobenzene-d5 (II) so as to prepare deuterium labeled aniline-d5 (III); (3) under the conditions of anhydrous sodium acetate and glacial acetic acid, subjecting the deuterium labeled aniline-d5 (III) and acetic anhydride to a reaction so as to prepare deuterium labeled N-acetanilide-d5 (IV); (4) subjecting the deuterium labeled N-acetanilide-d5 (IV) and chlorosulfonic acid to a reaction so as to prepare deuterium labeled 1-chlorosulfonyl-4-acetamidobenzene-d4 (V); and (5) allowing R to substitute chlorine of the deuterium labeled 1-chlorosulfonyl-4-acetamidobenzene-d4 (V), and carrying out hydrolysis so as to prepare an isotope deuterium labeled sulfanilamide drug (VII). The preparation method provided by the invention has the advantages of simple reaction conditions, short reaction time, highconversion efficiency, strong economy, and applicability to mass synthesis.
