1189747-33-8

Basic information

• Product Name: (α-D-mannopyranosyldithiomethylene)benzene
• Synonyms: (α-D-mannopyranosyldithiomethylene)benzene
• CAS NO: 1189747-33-8
• Molecular Weight: 318.415
• Mol File: 1189747-33-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (α-D-mannopyranosyldithiomethylene)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: (α-D-mannopyranosyldithiomethylene)benzene(1189747-33-8)
• EPA Substance Registry System: (α-D-mannopyranosyldithiomethylene)benzene(1189747-33-8)

Safety Data

• Hazardous Substances Data: 1189747-33-8(Hazardous Substances Data)

Upstream product

• 7559-62-8 S-benzyl methanethiosulfonate 
• 111057-34-2 sodium salt of 1-thio-α-D-mannose 

Relevant articles and documents

Interactions of aromatic mannosyl disulfide derivatives with Concanavalin A: synthesis, thermodynamic and NMR spectroscopy studies

α-d-Mannopyranosyl units were attached to an aromatic scaffold through disulfide linkages to obtain mono- to trivalent glycosylated ligands for lectin binding studies. Isothermal titration calorimetric (ITC) measurements indicated that binding affinities of these derivatives to Concanavalin A (Con A) were comparable to or slightly higher than that of methyl α-d-mannopyranoside (Ka values in the range of 104 M-1). The stoichiometries of the lectin-ligand complexes were in agreement with the formal valencies (1-3) of the respective ligands indicating cross-linking in interactions with the di- and trivalent derivatives. Multivalency effects could not, however, be observed with the latter. These ligands were shown to bind to the carbohydrate binding site of Con A using saturation transfer difference (STD) NMR competition experiments.