118993-93-4

Basic information

• Product Name: trans-1-phenyl-2-(4-pyridyl)cyclopropane
• CAS NO: 118993-93-4
• Molecular Weight: 195.264
• Mol File: 118993-93-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: trans-1-phenyl-2-(4-pyridyl)cyclopropane(CAS DataBase Reference)
• NIST Chemistry Reference: trans-1-phenyl-2-(4-pyridyl)cyclopropane(118993-93-4)
• EPA Substance Registry System: trans-1-phenyl-2-(4-pyridyl)cyclopropane(118993-93-4)

Safety Data

• Hazardous Substances Data: 118993-93-4(Hazardous Substances Data)

Upstream product

• 118993-93-4 trans-1-phenyl-2-(4-pyridyl)cyclopropane 
• 5097-93-8 trans-4-styrylpyride 
• 100-42-5 styrene 
• 19350-76-6 4-methyl-N′-(pyridin-3-ylmethylene)benzenesulfonohydrazide 

Downstream Products

• 118993-93-4 3-(2-phenylcyclopropyl)pyridine 

Relevant articles and documents

Intermolecular metal-free cyclopropanation of alkenes using tosylhydrazones

We describe the first general method for the metal-free cyclopropanation of alkenes by using N-tosylhydrazones as an in situ source of diazo compounds. This new method works with a wide variety of alkenes (styrene derivatives, dienes, enynes, and electron-deficient alkenes) by using N-tosylhydrazones derived from various ketones or aldehydes (aromatic, aliphatic, enones). The reaction is performed with the use of K2CO3 as a base to form the diazo species and is compatible with a wide array of functional groups. A new procedure for the synthesis of cyclopropanes by the formal cyclopropanation of carbonyl compounds and alkenes is described. This metal-free reaction proceeds through the base-promoted decomposition of tosylhydrazones. There is significant tolerance of the functional groups, enabling cyclopropanation in the presence of functionalities often not compatible with other methodologies.