1190-09-6

Basic information

• Product Name: (3-BROMOPROPYL)PHOSPHONIC ACID
• Synonyms: 3-BROMOPROPANEPHOSPHONIC ACID;(3-BROMOPROPYL)PHOSPHONIC ACID;PHOSPHONIC ACID, (3-BROMOPROPYL)-;Bromopropylphosphonicacid;Phosphonic acid,(3-broMopropyl)- (6CI,7CI,8CI,9CI)
• CAS NO: 1190-09-6
• Molecular Formula: C₃H₈BrO₃P
• Molecular Weight: 202.97
• Product Categories: Industrial/Fine Chemicals;Organic acids
• Mol File: 1190-09-6.mol

Chemical Properties

• Melting Point: 110.0 to 114.0 °C
• Boiling Point: 351.5°Cat760mmHg
• Flash Point: 166.4°C
• Appearance: /
• Density: g/cm³
• Vapor Pressure: 6.98E-06mmHg at 25°C
• PKA: 2.32±0.10(Predicted)
• CAS DataBase Reference: (3-BROMOPROPYL)PHOSPHONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (3-BROMOPROPYL)PHOSPHONIC ACID(1190-09-6)
• EPA Substance Registry System: (3-BROMOPROPYL)PHOSPHONIC ACID(1190-09-6)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 24/25-36/39-45-36/37/39-26
• RIDADR: 3261
• WGK Germany: 3
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 1190-09-6(Hazardous Substances Data)

Usage

Uses

Used in Chemical Synthesis:
(3-BROMOPROPYL)PHOSPHONIC ACID is used as a reagent for the synthesis of amino-substituted aromatic and aliphatic phosphonic acids. These compounds are important in various applications, including pharmaceuticals, agrochemicals, and materials science.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, (3-BROMOPROPYL)PHOSPHONIC ACID is used as a key intermediate in the synthesis of various drug molecules. Its ability to form amino-substituted phosphonic acids allows for the development of new therapeutic agents with potential applications in treating various diseases and medical conditions.
Used in Agrochemical Industry:
(3-BROMOPROPYL)PHOSPHONIC ACID is also utilized in the agrochemical industry for the synthesis of compounds with pesticidal properties. These synthesized compounds can be used as active ingredients in the development of new pesticides, herbicides, and other crop protection products.
Used in Materials Science:
In materials science, (3-BROMOPROPYL)PHOSPHONIC ACID can be used to synthesize novel materials with unique properties, such as improved thermal stability, chemical resistance, or mechanical strength. These materials can find applications in various industries, including automotive, aerospace, and electronics.

InChI:InChI=1/C3H8BrO3P/c4-2-1-3-8(5,6)7/h1-3H2,(H2,5,6,7)/p-2

Upstream product

• 109-64-8 1,3-dibromo-propane 
• 122-52-1 triethyl phosphite 
• 1186-10-3 diethyl 3-(bromopropyl)phosphonic acid 
• 118559-23-2 bis(trimethylsilyl) (3-bromopropyl)phosphonate 

Downstream Products

• 86483-94-5 (3-bromopropyl)phosphonic dichloride 
• 91054-44-3 (3-anilino-propyl)-phosphonic acid 

Relevant articles and documents

Microwave-assisted cleavage of phosphate, phosphonate and phosphoramide esters

A mild and rapid protocol for cleavage of phosphate, phosphonate and phosphoramide esters. The scope and limitations of this microwave-assisted reaction is explored here.

Materials comprising organic groups containing sulphur and phosphorous bonded to a mineral oxide via oxygen atoms

The invention describes materials comprising organic groups containing sulphur and phosphorous bonded together by a hydrocarbon chain and bonded via phosphorous and oxygen atoms to a mineral oxide of an element M, said materials being characterized in that they comprise M-O-M′ bonds, M′representing an element of a mineral oxide identical to or different from M, in that the ratio of the element M to the phosphorous is about 0.5: 1 to about 500:1 and in that each phosphorous atom of the phosphorous-containing groups forms at least one P—O-M bond and/or P—O-M′ bond. The invention also describes a process for preparing such materials.

Diaryl ester prodrugs of FR900098 with improved in vivo antimalarial activity

The fosmidomycin derivative FR900098 represents an inhibitor of the 1-deoxy-D-xylulose 5-phosphate (DOXP) reductoisomerase with potent antimalarial activity. Prodrugs of FR900098 with increased activity after oral administration were obtained by chemical modification of the phosphonate moiety to yield phosphodiaryl esters. One diaryl ester prodrug demonstrated efficacy in mice infected with the rodent malaria parasite Plasmodium vinckei comparable to ip drug administration.