1190042-34-2

Upstream product

• 478491-16-6 (3S)-4-(tert-butyldiphenylsilanyloxy)-(4-methoxybenzyloxy) butyraldehyde 
• 478491-17-7 (2E)(5S)-6-(tert-butyldiphenylsilanyloxy)-(4-methoxybenzyloxy)hex-2-enoic acid ethyl ester 
• 251571-56-9 [(S)-2-(4-methoxy-phenyl)-[1,3]dioxan-4-yl]-methanol 
• 221677-48-1 (3S)-4-[1-(tert-butyl)-1,1-diphenylsilyl]oxy-3-[(4-methoxybenzyl)oxy]butan-1-ol 
• 1190042-35-3 (5S)-5-[(4-methoxybenzyl)oxy-]6-heptenoic acid 
• 3521-91-3 (4R)-hept-1-en-ol 

Downstream Products

• 1190042-40-0 C₂₀H₂₈O₄ 
• 172104-03-9 putaminoxin 

Relevant academic research and scientific papers

Novel synthesis of stagonolide-F, putaminoxin and aspinolide-A

Novel synthesis of putaminoxin, stagonolide-F and aspinolide-A have been achieved by utilizing (S) and (R)- malic acid. The key feature of the synthetic strategy includes Horner-Wittig olefination, double bond reduction and Steglich esterification. Olefinic acid for putaminoxin and stagonolide-F was prepared from (S)-malic acid whereas olefinic acid for aspinolide-A was prepared from (R)-malic acid and olefinic alcohols for putaminoxin, stagonolide-F and aspinolide-A were prepared by using Brown's asymmetric allylboration.

The first total synthesis of putaminoxin and determination of its absolute configuration

Asymmetric synthesis of putaminoxin, a phytotoxic macrolide from the cultured dinoflagellate Amphidinium sp., has been accomplished. Absolute configuration of putaminoxin was concluded to be 1 from comparison of the NMR data and [α]D values of synthetic and natural putaminoxin.