119034-87-6Relevant academic research and scientific papers
BETA-2 SELECTIVE ADRENERGIC RECEPTOR AGONISTS
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Page/Page column 77-78, (2019/06/23)
Aspects of the present disclosure include conformationally restricted analogs of catecholamine type compounds (e.g., isoprenaline, adrenaline, noradrenaline) which activate β2AR with high selectivity over β1AR. The subject beta-2 selective adrenergic rece
Catalytic asymmetric synthesis of halenaquinone and halenaquinol
Kojima,Takemoto,Sodeoka,Shibasaki
, p. 581 - 589 (2007/10/03)
A catalytic asymmetric synthesis of halenaquinone (1) and halenaquinol (2) has been achieved using an asymmetric Heck reaction or a cascade Suzuki cross-coupling and an asymmetric Heck reaction as a key step. This synthesis also features the one-pot construction of a unique pentacyclic ring system from a tricyclic system using palladium chemistry. Moreover, the use of Ph3As as an achiral ligand has been found to enhance both the cascade Suzuki cross-coupling and also the Heck reaction to a synthetically useful extent.
Hexahydronaphth[1,2-b]-1,4-oxazines
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, (2008/06/13)
Hexahydronaphth[1,2-b]-1,4-oxazines have dopaminergic activity and display α 2 -adrenergic receptor antagonism. They are useful in the treatment of parkinsonism, depression and hypertension. An important method of preparation is by ring closure of the app
