1190709-19-3

Basic information

• Product Name: 5-methoxy-3-phenyl-1-(phenylsulfonyl)-1H-indole
• Synonyms: 5-methoxy-3-phenyl-1-(phenylsulfonyl)-1H-indole
• CAS NO: 1190709-19-3
• Molecular Weight: 363.437
• Mol File: 1190709-19-3.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 5-methoxy-3-phenyl-1-(phenylsulfonyl)-1H-indole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-methoxy-3-phenyl-1-(phenylsulfonyl)-1H-indole(1190709-19-3)
• EPA Substance Registry System: 5-methoxy-3-phenyl-1-(phenylsulfonyl)-1H-indole(1190709-19-3)

Safety Data

• Hazardous Substances Data: 1190709-19-3(Hazardous Substances Data)

Upstream product

• 591-50-4 iodobenzene 
• 56366-26-8 5-methoxy-3-phenyl-1Η-indole 
• 98-09-9 benzenesulfonyl chloride 
• 1006-94-6 5-methoxylindole 
• 85092-83-7 3-bromo-5-methoxy-1H-indole 
• 880771-40-4 3-bromo-5-methoxy-1-(phenylsulfonyl)-1H-indole 
• 98-80-6 phenylboronic acid 

Downstream Products

• 56366-26-8 5-methoxy-3-phenyl-1Η-indole 

Relevant articles and documents

Interfering with HuR-RNA Interaction: Design, Synthesis and Biological Characterization of Tanshinone Mimics as Novel, Effective HuR Inhibitors

The human antigen R (HuR) is an RNA-binding protein known to modulate the expression of target mRNA coding for proteins involved in inflammation, tumorigenesis, and stress responses and is a valuable drug target. We previously found that dihydrotanshinone

AZA-TANSHINONE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE IN THERAPY

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The synthesis of 2- and 3-aryl indoles and 1,3,4,5-tetrahydropyrano[4,3-b]indoles and their antibacterial and antifungal activity

A series of 2- and 3-aryl substituted indoles and two 1,3,4,5-tetrahydropyrano[4,3-b]indoles were synthesized from indole and 5-methoxyindole. The 2-aryl indoles were synthesized from the 1-(phenylsulfonyl)indole derivatives using magnesiation followed by iodination. The 2-iodinated compounds were then subjected to Suzuki-Miyaura reactions. In addition, the 3-aryl indoles were made from the corresponding 3-bromoindoles using Suzuki-Miyaura reactions. The 1,3,4,5-tetrahydropyrano[4,3-b]indoles were also synthesized from 1-(phenylsulfonyl)indole by magnesiation followed by treatment with allylbromide. The product was then converted into [2-allyl-1-(phenylsulfonyl)-1H-indol-3-yl]methanol which upon exposure to Hg(OAc)2 and NaBH4 afforded tetrahydropyrano[4,3-b]indoles. A number of the 2- and 3-aryl indoles displayed noteworthy antimicrobial activity, with compound 13a displaying the most significant activity (3.9 μg/mL) against the Gram-positive micro-organism Bacillus cereus.