1190878-76-2Relevant academic research and scientific papers
Tandem azide-alkyne 1,3-dipolar cycloaddition/electrophilic addition: A concise three-component route to 4,5-disubstituted triazolyl-nucleosides
Malnuit, Vincent,Duca, Maria,Manout, Anwar,Bougrin, Khalid,Benhida, Rachid
, p. 2123 - 2128 (2009)
A one-pot, three-component approach to a new family of 4,5-functionalized triazolyl-nucleosides is described. The method relies on the one-pot azide-alkyne 1,3-cycloaddition/electrophilic addition tandem reaction, which affords good yields of the correspo
In Vitro and in Vivo Evaluation of Fully Substituted (5-(3-Ethoxy-3-oxopropynyl)-4-(ethoxycarbonyl)-1,2,3-triazolyl-glycosides as Original Nucleoside Analogues to Circumvent Resistance in Myeloid Malignancies
Amdouni, Hella,Robert, Guillaume,Driowya, Mohsine,Furstoss, Nathan,Métier, Camille,Dubois, Alix,Dufies, Maeva,Zerhouni, Marwa,Orange, Fran?ois,Lacas-Gervais, Sandra,Bougrin, Khalid,Martin, Anthony R.,Auberger, Patrick,Benhida, Rachid
, p. 1523 - 1533 (2017)
A series of nucleoside analogues bearing a 1,4,5-trisubstituted-1,2,3-triazole aglycone was synthesized using a straightforward click/electrophilic addition or click/oxidative coupling tandem procedures. SAR analysis, using cell culture assays, led to the
ACADESINE DERIVATIVES, PRODUCTS AND COMPOSITIONS INCLUDING SAME, THERAPUETIC USES THEREOF, AND METHODS FOR SYNTHESIZING SAME
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, (2014/07/08)
Acadesine derivatives as a drug, as well as the derivatives for the treatment of cancer and in particular for the treatment of chronic myeloid leukemia are described. Also, product containing the derivatives and at least one second active ingredient as a
