1191-87-3Relevant articles and documents
Effects of hydration on the thermodynamic properties of aqueous ethylene glycol ether solutions
Schroedle, Simon,Hefter, Glenn,Buchner, Richard
, p. 513 - 522 (2005)
The densities and isobaric specific heat capacities of binary mixtures of water with various open-chain and cyclic ethylene glycol ethers have been measured at 298.15 K using vibrating tube densimetry, and flow or differential scanning calorimetry, respectively. Excess molar volumes were derived over the whole composition range. Molar isobaric heat capacities and the relative apparent thermodynamic quantities were determined in the water-rich region. The data reflect the changes in the structure and hydrogen-bond dynamics of water caused by these non-ionic solutes. The observed effects are discussed in terms of the influence of hydrophobic hydration on the thermodynamic properties of aqueous solutions. Correlations are given that enable the prediction of the thermodynamic properties of open-chain and cyclic oligo(ethylene oxide) ethers in their pure liquid state and at infinite dilution in water.
Kawauami et al.
, p. 3053 (1978)
METHOD FOR PRODUCING ALKYLENE GLYCOL DIETHERS
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Page/Page column 7-9, (2008/06/13)
The invention concerns a method for producing alkylene glycol diethers by reacting a linear or cyclic ether with an alkylene oxide in the presence of a Lewis acid. The invention is characterized in that the reaction is continuously carried out in a microreactor.
Investigations on the influence of 2'-O-alkyl modifications on the base pairing properties of oligonucleotides
Werner, Doris,Brunar, Helmut,Noe, Christian R.
, p. 3 - 10 (2007/10/03)
The antisense strategy has gained wide acceptance as a promising drug development concept. Antisense drugs hybridize with selected complementary sequences in a highly specific manner. However, as a main prerequisite for extensive therapeutic use of this new class of drugs, selected structural modifications are required to adjust pharmacokinetic and pharmacodynamic behavior. In continuation of our earlier investigations on 2'-O-modified oligonucleotides (Gotten, M., Oberhauser, B., Brunar, H., Holzner, A., Issakides, G., Noe, C.R., Schaffer, G., Wagner, E., Bimstiel, M.L., 1991. 2'-O-methyl, 2'-O-ethyl oligoribonucleotides and phosphorothioate oligodeoxyribonucleotides as inhibitors of the in vitro U7 snRNP-dependent mRNA processing event. Nucleic Acids Res. 19, 2629-2635; Wagner, E., Oberhauser, B., Holzner, A., Brunar, H., Issakides, G., Schaffner, G., Gotten, M., Knollmuller, M., Noe, C.R., 1991. A simple procedure for the preparation of protected 2'-O-methyl or 2'-O-ethyl ribonucleoside-3'-O-phosphoramidites. Nucleic Acids Res. 19, 5965-5971) further series of modified oligonucleotides containing different modified 2'-O-adenosines have been synthesized. On the one hand linear alkyl moieties of increasing length, on the other hand oxyethylene moieties of corresponding length were introduced at the 2'-O-position of adenosine. Following another approach a cationic charge was introduced by insertion of an aminohexylmodification at the 2'-O-position of adenosine (Brunar, H., Haberhauer, G., Werner, D., Noe, C.R., 1994. 2'-O-Modified oligonucleotides: Synthesis and biophysical analysis. Eur. J. Pharm. Sci. 2, 150). Molecule dynamics simulations had shown that this cationic modification upon duplex formation leads to both intra- and interstrand interactions. To determine the influence of the different modifications, such as cationic charge, alkyl chainlength and introduction of oxygen into the chain, on duplex stability melting temperatures were measured by recording circular dichroism versus temperature.