1191069-62-1Relevant academic research and scientific papers
Discovery of a novel series of CXCR3 antagonists
Crosignani, Stefano,Missotten, Marc,Cleva, Christophe,Dondi, Ruggero,Ratinaud, Yann,Humbert, Yves,Mandal, Ashis Baran,Bombrun, Agns,Power, Christine,Chollet, Andre,Proudfoot, Amanda
scheme or table, p. 3614 - 3617 (2010/09/17)
The discovery of a novel series of CXCR3 antagonists is described. Starting from an HTS positive, iterative optimization gave potent compounds (IC 50 15 nM in a chemotaxis assay). The strategy employed to improve the metabolic stability of these derivatives is described.
SULFONAMIDES
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, (2009/11/29)
The invention relates to compounds of formula (I) wherein R1, R2, R4, Ra, Rb, Rc, Re, A*, W1, W2 and W3 are as defined in claim 1, for the treatment of CXCR3 related diseases.
